Neuroblastoma (NB) is an infant tumor which frequently differentiates into neurons. We used two-dimensional differential in-gel electrophoresis (2D-DIGE) to analyze the cytosolic and nuclear protein expression patterns of LAN-5 cells following neuronal differentiating agent all-trans-retinoic acid treatment. We identified several candidate proteins, from which G beta 2 and Prefoldin 3 may have a role on NB development. These results strength the use of proteomics to discover new putative protein targets in cancer.
Comparative proteomic expression profile in all-trans retinoic acid differentiated neuroblastoma cellline / Cimmino, F; Spano, D; Capasso, Mario; Zambrano, Nicola; Russo, Roberta; Zollo, Massimo; Iolascon, Achille. - In: JOURNAL OF PROTEOME RESEARCH. - ISSN 1535-3893. - ELETTRONICO. - 6:7(2007), pp. 2550-2564. [10.1021/pr060701g]
Comparative proteomic expression profile in all-trans retinoic acid differentiated neuroblastoma cellline.
CAPASSO, Mario;ZAMBRANO, NICOLA;RUSSO, ROBERTA;ZOLLO, MASSIMO;IOLASCON, ACHILLE
2007
Abstract
Neuroblastoma (NB) is an infant tumor which frequently differentiates into neurons. We used two-dimensional differential in-gel electrophoresis (2D-DIGE) to analyze the cytosolic and nuclear protein expression patterns of LAN-5 cells following neuronal differentiating agent all-trans-retinoic acid treatment. We identified several candidate proteins, from which G beta 2 and Prefoldin 3 may have a role on NB development. These results strength the use of proteomics to discover new putative protein targets in cancer.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
