The AA. studied gentamycin serum levels (1mg/Kg b.w.) in rats. The 50% of the animals studied where treated with CCl4 (1 ml/Kg b;w.) 24h previously, the remaining 50% recieved a placebo. The maximum serum levels where similar in both groups; but the antibiotic was removed more slowly (120-240min) in the groups which recieved CCl4. The slower rimotion rate causes more serious histological changes in the kidney.
Changes in serum levels of antibiotics in experimental CCL4 poisoning. I. Gentamycin / G., Uomo; Roperto, FRANCO PEPPINO; A., Andini; D., Capasso; S., Esposito; P., Galloro; G., Guarino; O., Niola; E., Ricci. - In: BOLLETTINO DELLA SOCIETA' ITALIANA DI BIOLOGIA SPERIMENTALE. - ISSN 0037-8771. - ELETTRONICO. - 55:(1979), pp. 2118-2123.
Changes in serum levels of antibiotics in experimental CCL4 poisoning. I. Gentamycin
ROPERTO, FRANCO PEPPINO;
1979
Abstract
The AA. studied gentamycin serum levels (1mg/Kg b.w.) in rats. The 50% of the animals studied where treated with CCl4 (1 ml/Kg b;w.) 24h previously, the remaining 50% recieved a placebo. The maximum serum levels where similar in both groups; but the antibiotic was removed more slowly (120-240min) in the groups which recieved CCl4. The slower rimotion rate causes more serious histological changes in the kidney.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
