Activation of MC(1) /MC(3) receptors in C-20/A4 chondrocytes down-regulates the production of pro-inflammatory cytokines and cartilage destructive proteinases, inhibits initiation of apoptotic pathways and promotes release of chondroprotective/anti-inflammatory cytokines. Developing small molecule agonists to MC(1) / MC(3) receptors could be a viable approach for developing anti-inflammatory/chondroprotective therapies in rheumatoid and osteoarthritis

Chondroprotective and Anti-Inflammatory role of Melanocortin peptides in TNF-α activated human C-20/A4 chondrocytes.

GRIECO, PAOLO;
2012

Abstract

Activation of MC(1) /MC(3) receptors in C-20/A4 chondrocytes down-regulates the production of pro-inflammatory cytokines and cartilage destructive proteinases, inhibits initiation of apoptotic pathways and promotes release of chondroprotective/anti-inflammatory cytokines. Developing small molecule agonists to MC(1) / MC(3) receptors could be a viable approach for developing anti-inflammatory/chondroprotective therapies in rheumatoid and osteoarthritis
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/469032
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