Activation of MC(1) /MC(3) receptors in C-20/A4 chondrocytes down-regulates the production of pro-inflammatory cytokines and cartilage destructive proteinases, inhibits initiation of apoptotic pathways and promotes release of chondroprotective/anti-inflammatory cytokines. Developing small molecule agonists to MC(1) / MC(3) receptors could be a viable approach for developing anti-inflammatory/chondroprotective therapies in rheumatoid and osteoarthritis
Chondroprotective and Anti-Inflammatory role of Melanocortin peptides in TNF-α activated human C-20/A4 chondrocytes / Kaneva, M. K.; Kerrigan, M. J.; Grieco, Paolo; Curley, G. P.; Locke, I. C.; Getting, S. J.. - In: BRITISH JOURNAL OF PHARMACOLOGY. - ISSN 0007-1188. - 167:1(2012), pp. 67-79. [10.1111/j.1476-5381.2012.01968.x]
Chondroprotective and Anti-Inflammatory role of Melanocortin peptides in TNF-α activated human C-20/A4 chondrocytes.
GRIECO, PAOLO;
2012
Abstract
Activation of MC(1) /MC(3) receptors in C-20/A4 chondrocytes down-regulates the production of pro-inflammatory cytokines and cartilage destructive proteinases, inhibits initiation of apoptotic pathways and promotes release of chondroprotective/anti-inflammatory cytokines. Developing small molecule agonists to MC(1) / MC(3) receptors could be a viable approach for developing anti-inflammatory/chondroprotective therapies in rheumatoid and osteoarthritisI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
