N-Ribosyltransferase inhibition represents a target of broad pharmacological relevance, given the crucial role of such enzymes in a number of disease-related events [1]. This is exemplified by the case of Immucillin-H, which picomolar activity has been exploited for diverse therapeutic purposes, e.g. treatment of leukemia, parasite-mediated diseases and autoimmune disorders. Herein a domino approach to the synthesis of novel iminosugar-based nucleoside, analogues of immucilin-H is proposed.
Domino approach to a novel class of N-ribosyltransferase transition state analogues / Dell'Isola, A.; Guaragna, Annalisa; D'Alonzo, Daniele; Paolella, Concetta; Palumbo, Giovanni. - (2011). (Intervento presentato al convegno 16th European Carbohydrate Symposium (EUROCARB) tenutosi a Sorrento (NA) nel 3-7 luglio 2011).
Domino approach to a novel class of N-ribosyltransferase transition state analogues
GUARAGNA, ANNALISA;D'ALONZO, DANIELE;PAOLELLA, CONCETTA;PALUMBO, GIOVANNI
2011
Abstract
N-Ribosyltransferase inhibition represents a target of broad pharmacological relevance, given the crucial role of such enzymes in a number of disease-related events [1]. This is exemplified by the case of Immucillin-H, which picomolar activity has been exploited for diverse therapeutic purposes, e.g. treatment of leukemia, parasite-mediated diseases and autoimmune disorders. Herein a domino approach to the synthesis of novel iminosugar-based nucleoside, analogues of immucilin-H is proposed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
