Background: Primary orbital lymphoma is a rare disease that accounts for 10% of all orbital tumors. Radiotherapy on the orbital cavity is the treatment of choice for this unusual presentation of localized non-Hodgkin's lymphoma (NHL). The aim of this study is to retrospectively evaluate the effectiveness and the toxicity of radiation treatment in patients with primary orbital lymphoma. Methods: Forty-seven consecutive patients having primary orbital lymphoma treated in our department between May 1983 and September 2006 were investigated in a retrospective study. Either (60)Co gamma rays or 6 MV X rays were used to deliver daily fractions of 1.8 or 2.0 Gy, 5 times/week, with total doses ranging from 34.2 to 50 Gy. Forty-three patients had stage IE, three had stage II and one stage IV disease. Thirty-eight patients had marginal zone B-cell lymphoma, 5 diffuse large B cell lymphoma, 3 mantle cell lymphoma and 1 Burkitt lymphoma. Local control (LC), disease free survival (DFS), overall survival (OS) and late side effects were evaluated in all patients. Results: With a median follow up of 45 months, LC was obtained in 100% of patients. The estimated 5-and 7-year DFS rates were 75.8% and 55.3%, and the 5-and 7-year OS rates were 88.7% and 79.9% respectively. Acute toxicity was minimal. Late toxicity such as cataract, keratitis, retinopathy and xerophthalmia occurred respectively in 12 (25.5%), 5 (10.6%), 1 (2.1%), and 9 (19.1%) patients

Radiation therapy in primary orbital lymphoma: a single institution retrospective analysis / De Cicco, L.; Cella, L.; Liuzzi, R.; Solla, R.; Farella, A.; Punzo, G.; Tranfa, Fausto; Strianese, Diego; Conson, Manuel; Bonavolontà, G.; Salvatore, Marco; Pacelli, Roberto. - In: RADIATION ONCOLOGY. - ISSN 1748-717X. - ELETTRONICO. - 4:(2009), pp. 60-65. [10.1186/1748-717X-4-60]

Radiation therapy in primary orbital lymphoma: a single institution retrospective analysis.

TRANFA, FAUSTO;STRIANESE, DIEGO;CONSON, MANUEL;SALVATORE, MARCO;PACELLI, ROBERTO
2009

Abstract

Background: Primary orbital lymphoma is a rare disease that accounts for 10% of all orbital tumors. Radiotherapy on the orbital cavity is the treatment of choice for this unusual presentation of localized non-Hodgkin's lymphoma (NHL). The aim of this study is to retrospectively evaluate the effectiveness and the toxicity of radiation treatment in patients with primary orbital lymphoma. Methods: Forty-seven consecutive patients having primary orbital lymphoma treated in our department between May 1983 and September 2006 were investigated in a retrospective study. Either (60)Co gamma rays or 6 MV X rays were used to deliver daily fractions of 1.8 or 2.0 Gy, 5 times/week, with total doses ranging from 34.2 to 50 Gy. Forty-three patients had stage IE, three had stage II and one stage IV disease. Thirty-eight patients had marginal zone B-cell lymphoma, 5 diffuse large B cell lymphoma, 3 mantle cell lymphoma and 1 Burkitt lymphoma. Local control (LC), disease free survival (DFS), overall survival (OS) and late side effects were evaluated in all patients. Results: With a median follow up of 45 months, LC was obtained in 100% of patients. The estimated 5-and 7-year DFS rates were 75.8% and 55.3%, and the 5-and 7-year OS rates were 88.7% and 79.9% respectively. Acute toxicity was minimal. Late toxicity such as cataract, keratitis, retinopathy and xerophthalmia occurred respectively in 12 (25.5%), 5 (10.6%), 1 (2.1%), and 9 (19.1%) patients
2009
Radiation therapy in primary orbital lymphoma: a single institution retrospective analysis / De Cicco, L.; Cella, L.; Liuzzi, R.; Solla, R.; Farella, A.; Punzo, G.; Tranfa, Fausto; Strianese, Diego; Conson, Manuel; Bonavolontà, G.; Salvatore, Marco; Pacelli, Roberto. - In: RADIATION ONCOLOGY. - ISSN 1748-717X. - ELETTRONICO. - 4:(2009), pp. 60-65. [10.1186/1748-717X-4-60]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/424152
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