Algal toxins (phycotoxins) pose a serious threat to shellfish consumers and have caused significant financial losses to the shellfish industry over the last years. Public health and economic impacts of these incidents which occur with alarming frequency throughout the world have aroused scientists??? growing interest. Particularly, the identification and geographic distribution of phycotoxins in seafood are currently receiving worldwide attention. Typically, the identified toxins are classified according to the poisoning syndromes that they cause which have been named paralytic-, diarrhetic-, neurotoxic- and amnesic-shellfish poisoning (PSP, DSP, NSP, and ASP respectively). Phycotoxins profile in the different geographical areas is associated to the species of microalgae blooming in the sea and to environmental conditions which allow their growth. PSP is the most widespread poisoning on a worldwide basis with toxic incidents being reported in Europe, Asia, Australia and New Zealand as well as along both Atlantic and Pacific coasts of the Americas. Similarly, DSP is widespread in its distribution with essentially seasonal occurrences in Europe and Japan. A more limited occurrence has been reported for NSP and ASP toxins. Particularly, brevetoxins associated to NSP, have historically been detected along west coast of Florida and Gulf of Mexico, with a single outbreak being reported in New Zealand. Domoic acid (DA), the causative toxin of ASP syndrome, is currently limited in its distribution to North America east and west coasts. In Italy, a monitoring program for marine toxins in shellfish from Adriatic sea has indicated that contamination is mainly due to DSP and associated toxins. In particular, since 1995 yessotoxin and its analogues have been indicated as the main contaminants of Adriatic mussels. Within a research programme aimed to outline the complete toxins profile of Adriatic mussels, we investigated the presence of marine toxins at levels even below those established by the regulatory settings. The present communication reports on domoic acid as a new phycotoxin which has entered the Adriatic mussels toxin profile. Samples of Mytilus galloprovincialis collected in the gulf of Trieste and along Emilia Romagna coasts over a three years period were analyzed. Detection was carried out basing on hydrophilic interaction liquid chromatography-mass spectrometry (HILIC-MS) technique.

First Occurrence of Domoic Acid in Mytilus galloprovincialis from northern Adriatic sea revealed by HILIC-MS / Dell'Aversano, Carmela; Ciminiello, Patrizia; Fattorusso, Ernesto; Forino, Martino; S., Magno; Tartaglione, Luciana; A., Tubaro; G. M., Altimier; R., Poletti. - (2004), pp. 23-23. (Intervento presentato al convegno XI International symposium on Marine Natural Products tenutosi a Sorrento (NA) nel 4-9/9/2004).

First Occurrence of Domoic Acid in Mytilus galloprovincialis from northern Adriatic sea revealed by HILIC-MS

DELL'AVERSANO, CARMELA;CIMINIELLO, PATRIZIA;FATTORUSSO, ERNESTO;FORINO, MARTINO;TARTAGLIONE, LUCIANA;
2004

Abstract

Algal toxins (phycotoxins) pose a serious threat to shellfish consumers and have caused significant financial losses to the shellfish industry over the last years. Public health and economic impacts of these incidents which occur with alarming frequency throughout the world have aroused scientists??? growing interest. Particularly, the identification and geographic distribution of phycotoxins in seafood are currently receiving worldwide attention. Typically, the identified toxins are classified according to the poisoning syndromes that they cause which have been named paralytic-, diarrhetic-, neurotoxic- and amnesic-shellfish poisoning (PSP, DSP, NSP, and ASP respectively). Phycotoxins profile in the different geographical areas is associated to the species of microalgae blooming in the sea and to environmental conditions which allow their growth. PSP is the most widespread poisoning on a worldwide basis with toxic incidents being reported in Europe, Asia, Australia and New Zealand as well as along both Atlantic and Pacific coasts of the Americas. Similarly, DSP is widespread in its distribution with essentially seasonal occurrences in Europe and Japan. A more limited occurrence has been reported for NSP and ASP toxins. Particularly, brevetoxins associated to NSP, have historically been detected along west coast of Florida and Gulf of Mexico, with a single outbreak being reported in New Zealand. Domoic acid (DA), the causative toxin of ASP syndrome, is currently limited in its distribution to North America east and west coasts. In Italy, a monitoring program for marine toxins in shellfish from Adriatic sea has indicated that contamination is mainly due to DSP and associated toxins. In particular, since 1995 yessotoxin and its analogues have been indicated as the main contaminants of Adriatic mussels. Within a research programme aimed to outline the complete toxins profile of Adriatic mussels, we investigated the presence of marine toxins at levels even below those established by the regulatory settings. The present communication reports on domoic acid as a new phycotoxin which has entered the Adriatic mussels toxin profile. Samples of Mytilus galloprovincialis collected in the gulf of Trieste and along Emilia Romagna coasts over a three years period were analyzed. Detection was carried out basing on hydrophilic interaction liquid chromatography-mass spectrometry (HILIC-MS) technique.
2004
First Occurrence of Domoic Acid in Mytilus galloprovincialis from northern Adriatic sea revealed by HILIC-MS / Dell'Aversano, Carmela; Ciminiello, Patrizia; Fattorusso, Ernesto; Forino, Martino; S., Magno; Tartaglione, Luciana; A., Tubaro; G. M., Altimier; R., Poletti. - (2004), pp. 23-23. (Intervento presentato al convegno XI International symposium on Marine Natural Products tenutosi a Sorrento (NA) nel 4-9/9/2004).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/413293
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