AIM: To evaluate cardiac function and structure in untreated human immunodeficiency virus (HIV) patients without clinical evidence of cardiovascular disease. METHODS: Fifty-three naïve untreated HIV-infected patients and 56 healthy control subjects underwent clinical assessment, electrocardiography (ECG) and echocardiography, including tissue doppler imaging. Moreover, a set of laboratory parameters was obtained from all subjects, including HIV-RNA plasma levels, CD4 cell counts and tumor necrosis factor-α levels. RESULTS: The two groups showed normal ECG traces and no differences regarding systolic morphologic parameters. In contrast, a higher prevalence of left ventricular diastolic dysfunction (abnormal relaxation or pseudonormal filling pattern) was found in the HIV patients (36% vs 9% in patients and controls, respectively, P <0.001). CONCLUSION: Subclinical cardiac abnormalities appear in an early stage of the HIV infection, independent of antiretroviral therapy. The data suggest that HIV per se plays a role in the genesis of diastolic dysfunction.

Impaired diastolic function in naïve untreated human immunodeficiency virus infected patients / Oliviero, Ugo; Bonadies, G; Bosso, Giorgio; Foggia, M; Apuzzi, Valentina; Cotugno, M; Valvano, Antonio; Leonardi, E; Borgia, Guglielmo; Castello, G; Napoli, Raffaele; Sacca', Luigi. - In: WORLD JOURNAL OF CARDIOLOGY. - ISSN 1949-8462. - ELETTRONICO. - 2:4(2010), pp. 98-103. [10.4330/wjc.v2.i4.98]

Impaired diastolic function in naïve untreated human immunodeficiency virus infected patients.

OLIVIERO, UGO;BOSSO, GIORGIO;APUZZI, valentina;VALVANO, ANTONIO;BORGIA, GUGLIELMO;NAPOLI, RAFFAELE;SACCA', LUIGI
2010

Abstract

AIM: To evaluate cardiac function and structure in untreated human immunodeficiency virus (HIV) patients without clinical evidence of cardiovascular disease. METHODS: Fifty-three naïve untreated HIV-infected patients and 56 healthy control subjects underwent clinical assessment, electrocardiography (ECG) and echocardiography, including tissue doppler imaging. Moreover, a set of laboratory parameters was obtained from all subjects, including HIV-RNA plasma levels, CD4 cell counts and tumor necrosis factor-α levels. RESULTS: The two groups showed normal ECG traces and no differences regarding systolic morphologic parameters. In contrast, a higher prevalence of left ventricular diastolic dysfunction (abnormal relaxation or pseudonormal filling pattern) was found in the HIV patients (36% vs 9% in patients and controls, respectively, P <0.001). CONCLUSION: Subclinical cardiac abnormalities appear in an early stage of the HIV infection, independent of antiretroviral therapy. The data suggest that HIV per se plays a role in the genesis of diastolic dysfunction.
2010
Impaired diastolic function in naïve untreated human immunodeficiency virus infected patients / Oliviero, Ugo; Bonadies, G; Bosso, Giorgio; Foggia, M; Apuzzi, Valentina; Cotugno, M; Valvano, Antonio; Leonardi, E; Borgia, Guglielmo; Castello, G; Napoli, Raffaele; Sacca', Luigi. - In: WORLD JOURNAL OF CARDIOLOGY. - ISSN 1949-8462. - ELETTRONICO. - 2:4(2010), pp. 98-103. [10.4330/wjc.v2.i4.98]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/412921
Citazioni
  • ???jsp.display-item.citation.pmc??? 5
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact