Synthesis of selective chemotherapeutic agents for antitumor and antiviral therapy purposes has been herein accomplished. Particularly, some novel molecular systems have been developed: Folic acid based chlorambucil conjugates for selective antitumor treatments. Folic acid based 5-aminolevulinic acid derivatives for photodynamic therapy of tumor cells. 4'-Substituted nucleosides and 2'3'-dihydro-1,4-dithiinyl nucleosides analogues for antiviral therapies. Six-membered sugar based modified oligonucleotides: ribo-CNA, (ribo-Cyclohexanyl Nucleic Acids)for gene expression control
Design and synthesis of new selective chemotherapeutic agents / Guaragna, Annalisa. - (2011).
Design and synthesis of new selective chemotherapeutic agents
GUARAGNA, ANNALISA
2011
Abstract
Synthesis of selective chemotherapeutic agents for antitumor and antiviral therapy purposes has been herein accomplished. Particularly, some novel molecular systems have been developed: Folic acid based chlorambucil conjugates for selective antitumor treatments. Folic acid based 5-aminolevulinic acid derivatives for photodynamic therapy of tumor cells. 4'-Substituted nucleosides and 2'3'-dihydro-1,4-dithiinyl nucleosides analogues for antiviral therapies. Six-membered sugar based modified oligonucleotides: ribo-CNA, (ribo-Cyclohexanyl Nucleic Acids)for gene expression controlI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
