In a screening of potential targets within Notch signaling, miR-34a was seen to be a regulator of the Notch pathway through its targeting of Notch ligand Delta-like 1 (Dll1). Down-regulation of Dll1 expression by miR-34a negatively regulates cell proliferation, and induces apoptosis and neural differentiation in MB cells. MiR-34a expression negatively affects CD133+/CD15+ tumor-propagating cells. Adenoviruses carrying the precursor miR-34a induce neurogenesis of tumor spheres derived from a genetic animal model of MB (Patch1+/- p53-/-), thus providing further evidence that the miR-34a/Dll1 axis controls both autonomous and non autonomous signaling of Notch. In vivo, miR-34a overexpression carried by adenoviruses reduces tumor burden in cerebellum xenografts of athymic mice, thus demonstrating an anti-tumorigenic role of miR-34a in vivo.

MiR-34a Targeting of Notch Ligand Delta-Like 1 ImpairsCD15+/CD133+ Tumor-Propagating Cells and SupportsNeural Differentiation in / de Antonellis, P.; Medaglia, C.; Cusanelli, E.; Andolfo, I.; Liguori, L.; DE VITA, Gennaro; Carotenuto, M.; Bello, A.; Formiggini, F.; Galeone, Aldo; DE ROSA, Giuseppe; Virgilio, Antonella; Scognamiglio, I.; Sciro, M.; Basso, G.; Schulte, J. H.; Cinalli, G.; Iolascon, Achille; Zollo, Massimo. - In: PLOS ONE. - ISSN 1932-6203. - (2011), pp. 1-17. [10.1371/journal.pone.0024584]

MiR-34a Targeting of Notch Ligand Delta-Like 1 ImpairsCD15+/CD133+ Tumor-Propagating Cells and SupportsNeural Differentiation in

P. de Antonellis;I. Andolfo;DE VITA, GENNARO;GALEONE, ALDO;DE ROSA, GIUSEPPE;VIRGILIO, ANTONELLA;IOLASCON, ACHILLE;ZOLLO, MASSIMO
2011

Abstract

In a screening of potential targets within Notch signaling, miR-34a was seen to be a regulator of the Notch pathway through its targeting of Notch ligand Delta-like 1 (Dll1). Down-regulation of Dll1 expression by miR-34a negatively regulates cell proliferation, and induces apoptosis and neural differentiation in MB cells. MiR-34a expression negatively affects CD133+/CD15+ tumor-propagating cells. Adenoviruses carrying the precursor miR-34a induce neurogenesis of tumor spheres derived from a genetic animal model of MB (Patch1+/- p53-/-), thus providing further evidence that the miR-34a/Dll1 axis controls both autonomous and non autonomous signaling of Notch. In vivo, miR-34a overexpression carried by adenoviruses reduces tumor burden in cerebellum xenografts of athymic mice, thus demonstrating an anti-tumorigenic role of miR-34a in vivo.
2011
MiR-34a Targeting of Notch Ligand Delta-Like 1 ImpairsCD15+/CD133+ Tumor-Propagating Cells and SupportsNeural Differentiation in / de Antonellis, P.; Medaglia, C.; Cusanelli, E.; Andolfo, I.; Liguori, L.; DE VITA, Gennaro; Carotenuto, M.; Bello, A.; Formiggini, F.; Galeone, Aldo; DE ROSA, Giuseppe; Virgilio, Antonella; Scognamiglio, I.; Sciro, M.; Basso, G.; Schulte, J. H.; Cinalli, G.; Iolascon, Achille; Zollo, Massimo. - In: PLOS ONE. - ISSN 1932-6203. - (2011), pp. 1-17. [10.1371/journal.pone.0024584]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/398485
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