The resistance of human colon adenocarcinoma cells to antineoplastic agents may be related to the high endogenous expression of stress proteins, including the family of heat shock proteins (HSPs). Recently, a quinone-based pentacyclic derivative, DTNQ-Pro, showed high cytotoxic activity in human colon carcinoma cell lines. The aim of the present study was to determine the precise cellular mechanisms of this cytotoxic action of DTNQ-Pro.
A novel quinone–based derivative (DTNQ-Pro) induces apoptotic death via modulation/reduction of hsp expression in a human colon adenocarcinoma cell line / GOMEZ MONTERREY, ISABEL MARIA; P., Campiglia; Bertamino, Alessia; Aquino, Claudio; M., Sala; Grieco, Paolo; A., Dicitore; D., Vanacore; A., Porta; B., Maresca; Novellino, Ettore; P., Stiuso. - In: BRITISH JOURNAL OF PHARMACOLOGY. - ISSN 0007-1188. - 4:160(2010), pp. 931-940. [10.1111/j.1476-5381.2010.00718.x]
A novel quinone–based derivative (DTNQ-Pro) induces apoptotic death via modulation/reduction of hsp expression in a human colon adenocarcinoma cell line
GOMEZ MONTERREY, ISABEL MARIA;BERTAMINO, ALESSIA;AQUINO, CLAUDIO;GRIECO, PAOLO;NOVELLINO, ETTORE;
2010
Abstract
The resistance of human colon adenocarcinoma cells to antineoplastic agents may be related to the high endogenous expression of stress proteins, including the family of heat shock proteins (HSPs). Recently, a quinone-based pentacyclic derivative, DTNQ-Pro, showed high cytotoxic activity in human colon carcinoma cell lines. The aim of the present study was to determine the precise cellular mechanisms of this cytotoxic action of DTNQ-Pro.| File | Dimensione | Formato | |
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