Dr. Nicola Borbone presented the research activities focalized on DNA quadruplexes run in the laboratories of the School of Pharmacy of the University of Napoli “Federico II”. During his talk Dr. Borbone discussed the following topics: 1. Instrumentation available at the School of Pharmacy in Napoli. 2. Synthesis of DNA putative quadruplex sequences containing modified residues. 3. Synthesis of Tetra-End-Linked (TEL) monomolecular quadruplexes. 4. Synthesis of PNAs capable to bind to DNA quadruplexes as quadruplex ligands. 5. Construction of TEL-ODN based nanodevices to be used as novel biosensors. 6. Synthesis of TEL-aptamers and short PNAs to be used as novel anticancer drugs.
Synthesis, characterization and biological activities of DNA G-quadruplexes / Borbone, Nicola. - (2009). (Intervento presentato al convegno COST Action MP0802: Kick-off Meeting of Working Groups tenutosi a Hotel Lycium, Debrecen, Hungary nel 25-27 marzo 2009).
Synthesis, characterization and biological activities of DNA G-quadruplexes
BORBONE, NICOLA
2009
Abstract
Dr. Nicola Borbone presented the research activities focalized on DNA quadruplexes run in the laboratories of the School of Pharmacy of the University of Napoli “Federico II”. During his talk Dr. Borbone discussed the following topics: 1. Instrumentation available at the School of Pharmacy in Napoli. 2. Synthesis of DNA putative quadruplex sequences containing modified residues. 3. Synthesis of Tetra-End-Linked (TEL) monomolecular quadruplexes. 4. Synthesis of PNAs capable to bind to DNA quadruplexes as quadruplex ligands. 5. Construction of TEL-ODN based nanodevices to be used as novel biosensors. 6. Synthesis of TEL-aptamers and short PNAs to be used as novel anticancer drugs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
