This paper reports on the analysis of the toxin content from Palythoa tuberculosa and Palythoa toxica samples collected off of the Hawaiian coast. Our work, based on in-depth high-resolution liquid chromatography-mass spectrometry analysis along with extensive NMR study, led us to structurally characterize 42-hydroxy-palytoxin, a new palytoxin congener. This toxin and palytoxin itself appeared to be the major components of toxic extract from a P. tuberculosa sample, while 42-hydroxy-palytoxin was proven by far to be the main palytoxin derivative in P. toxica. Functional studies on this new palytoxin-like compound suggest that the new palytoxin analogue and palytoxin itself present similar biological activities.
Stereostructure and Biological Activity of 42-Hydroxy-palytoxin: a new palytoxin analogue from Hawaiian Palythoa subspecies / Ciminiello, P., Dell'Aversano, C., Dello Iacovo, E., Fattorusso, E., Forino, M., Grauso, L., Tartaglione, L., Florio, C., Lorenzon, P., De Bortoli, M., Tubaro, A., Poli, M., Bignami, G.. - In: CHEMICAL RESEARCH IN TOXICOLOGY. - ISSN 0893-228X. - STAMPA. - 22:(2009), pp. 1851-1859. [10.1021/tx900259v]
Stereostructure and Biological Activity of 42-Hydroxy-palytoxin: a new palytoxin analogue from Hawaiian Palythoa subspecies
CIMINIELLO, PATRIZIA;DELL'AVERSANO, CARMELA;FATTORUSSO, ERNESTO;FORINO, MARTINO;L. Grauso;TARTAGLIONE, LUCIANA;
2009
Abstract
This paper reports on the analysis of the toxin content from Palythoa tuberculosa and Palythoa toxica samples collected off of the Hawaiian coast. Our work, based on in-depth high-resolution liquid chromatography-mass spectrometry analysis along with extensive NMR study, led us to structurally characterize 42-hydroxy-palytoxin, a new palytoxin congener. This toxin and palytoxin itself appeared to be the major components of toxic extract from a P. tuberculosa sample, while 42-hydroxy-palytoxin was proven by far to be the main palytoxin derivative in P. toxica. Functional studies on this new palytoxin-like compound suggest that the new palytoxin analogue and palytoxin itself present similar biological activities.| File | Dimensione | Formato | |
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