Five new steroidal alkaloids, plakinamines C (1) and D (2), and the related compounds 3-5 have been isolated from the Vanuatu sponge Corticium sp. Their structures have been elucidated by a detailed spectroscopic analysis. The new compounds show significant in vitro cytotoxicity against human bronchopulmonary non-small-cell lung carcinoma cells (NSCLC-NG) with IC50 values of < 3.3-5.7 mu g/mL. When tested against T leukemia virus type one (HTLV-I), compounds 1, 4 and 5 were found to exhibit slight anti-HIV activity.
Plakinamines C and D and three other steroidal alkaloids from the sponge Corticium sp / DE MARINO, Simona; M., Iorizzi; Zollo, Franco; C., Roussakis; C., Debitus. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - STAMPA. - (1999), pp. 697-701.
Plakinamines C and D and three other steroidal alkaloids from the sponge Corticium sp
DE MARINO, SIMONA;ZOLLO, FRANCO;
1999
Abstract
Five new steroidal alkaloids, plakinamines C (1) and D (2), and the related compounds 3-5 have been isolated from the Vanuatu sponge Corticium sp. Their structures have been elucidated by a detailed spectroscopic analysis. The new compounds show significant in vitro cytotoxicity against human bronchopulmonary non-small-cell lung carcinoma cells (NSCLC-NG) with IC50 values of < 3.3-5.7 mu g/mL. When tested against T leukemia virus type one (HTLV-I), compounds 1, 4 and 5 were found to exhibit slight anti-HIV activity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
