Five new steroidal alkaloids, plakinamines C (1) and D (2), and the related compounds 3-5 have been isolated from the Vanuatu sponge Corticium sp. Their structures have been elucidated by a detailed spectroscopic analysis. The new compounds show significant in vitro cytotoxicity against human bronchopulmonary non-small-cell lung carcinoma cells (NSCLC-NG) with IC50 values of < 3.3-5.7 mu g/mL. When tested against T leukemia virus type one (HTLV-I), compounds 1, 4 and 5 were found to exhibit slight anti-HIV activity.

Plakinamines C and D and three other steroidal alkaloids from the sponge Corticium sp

DE MARINO, SIMONA;ZOLLO, FRANCO;
1999

Abstract

Five new steroidal alkaloids, plakinamines C (1) and D (2), and the related compounds 3-5 have been isolated from the Vanuatu sponge Corticium sp. Their structures have been elucidated by a detailed spectroscopic analysis. The new compounds show significant in vitro cytotoxicity against human bronchopulmonary non-small-cell lung carcinoma cells (NSCLC-NG) with IC50 values of < 3.3-5.7 mu g/mL. When tested against T leukemia virus type one (HTLV-I), compounds 1, 4 and 5 were found to exhibit slight anti-HIV activity.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/357176
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