The expression of sigma-2 receptors was investigated in nine urothelial tumours of the urinary bladder of cattle. Each tumour was associated with the presence of DNA of bovine papillomavirus type-2 (BPV-2) and expression of the E5 viral oncoprotein. Five tumours were classified as low-grade carcinoma on the basis of morphological criteria and calculation of mean nuclear area (MNA) and mean nuclear perimeter (MNP). Four tumours were classified as high-grade carcinoma. Sigma-2 receptors were overexpressed in both types of carcinoma. In control normal bovine bladder tissue the density of receptors (expressed as the B(max)) was 0.37 pmol/mg of protein. Low-grade carcinomas had a mean B(max) of 1.37+/-0.32 pmol/mg of protein (range 1.03-1.86) and in high-grade carcinomas the mean B(max) was 10.9+/-2.8 pmol/mg of protein (range 8.2-14). The difference in B(max) between low- and high-grade carcinomas was statistically significant (P=0.0001).
Sigma-2 Receptor Expression in Bovine Papillomavirus-Associated Urinary Bladder Tumours / Roperto, Sante; Colabufo, N. A.; Inglese, C.; Urraro, Chiara; Brun, R.; Mezza, E.; Staibano, S.; Raso, C.; Maiolino, Paola; Russo, Valeria; Palma, E.; Roperto, FRANCO PEPPINO. - In: JOURNAL OF COMPARATIVE PATHOLOGY. - ISSN 0021-9975. - ELETTRONICO. - 142:1(2010), pp. 9-18.
Sigma-2 Receptor Expression in Bovine Papillomavirus-Associated Urinary Bladder Tumours.
ROPERTO, SANTE;URRARO, chiara;S. Staibano;MAIOLINO, PAOLA;RUSSO, VALERIA;ROPERTO, FRANCO PEPPINO
2010
Abstract
The expression of sigma-2 receptors was investigated in nine urothelial tumours of the urinary bladder of cattle. Each tumour was associated with the presence of DNA of bovine papillomavirus type-2 (BPV-2) and expression of the E5 viral oncoprotein. Five tumours were classified as low-grade carcinoma on the basis of morphological criteria and calculation of mean nuclear area (MNA) and mean nuclear perimeter (MNP). Four tumours were classified as high-grade carcinoma. Sigma-2 receptors were overexpressed in both types of carcinoma. In control normal bovine bladder tissue the density of receptors (expressed as the B(max)) was 0.37 pmol/mg of protein. Low-grade carcinomas had a mean B(max) of 1.37+/-0.32 pmol/mg of protein (range 1.03-1.86) and in high-grade carcinomas the mean B(max) was 10.9+/-2.8 pmol/mg of protein (range 8.2-14). The difference in B(max) between low- and high-grade carcinomas was statistically significant (P=0.0001).File | Dimensione | Formato | |
---|---|---|---|
sigma 2.pdf
non disponibili
Tipologia:
Documento in Post-print
Licenza:
Accesso privato/ristretto
Dimensione
675.84 kB
Formato
Adobe PDF
|
675.84 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.