Investigation of the marine sponge Coscinoderma mathewsi led to the isolation of two novel nitrogen-containing cheilanthane sesterterpenoids, coscinolactams A and B, together with known suvanine. The structures were elucidated by extensive spectroscopic measurements including NOE experiments to deduce the stereochemistry. The natural compounds, as well as a semisynthetic derivative, showed moderate anti-inflammatory activity measured as their capability to inhibit PGE2 and NO production. The suvanine aldehyde derivative 4 inhibited inducible nitric oxide protein expression with an IC50 value of 7.3 μM.

Coscinolactams A and B: new nitrogen-containing sesterterpenoids from the marine sponge Coscinoderma mathewsi exerting anti-inflammatory properties / De Marino, S.; Festa, Carmen; D'Auria, M. V.; Bourguet-Kondracki, M. L.; Petek, S.; Debitus, C.; Andres, R. M.; Terencio, M. C.; Paya, M.; Zampella, A.. - In: TETRAHEDRON. - ISSN 0040-4020. - 65:15(2009), pp. 2905-2909. [10.1016/j.tet.2009.02.016]

Coscinolactams A and B: new nitrogen-containing sesterterpenoids from the marine sponge Coscinoderma mathewsi exerting anti-inflammatory properties

S. De Marino;Carmen Festa;M. V. D'Auria;A. Zampella
2009

Abstract

Investigation of the marine sponge Coscinoderma mathewsi led to the isolation of two novel nitrogen-containing cheilanthane sesterterpenoids, coscinolactams A and B, together with known suvanine. The structures were elucidated by extensive spectroscopic measurements including NOE experiments to deduce the stereochemistry. The natural compounds, as well as a semisynthetic derivative, showed moderate anti-inflammatory activity measured as their capability to inhibit PGE2 and NO production. The suvanine aldehyde derivative 4 inhibited inducible nitric oxide protein expression with an IC50 value of 7.3 μM.
2009
Coscinolactams A and B: new nitrogen-containing sesterterpenoids from the marine sponge Coscinoderma mathewsi exerting anti-inflammatory properties / De Marino, S.; Festa, Carmen; D'Auria, M. V.; Bourguet-Kondracki, M. L.; Petek, S.; Debitus, C.; Andres, R. M.; Terencio, M. C.; Paya, M.; Zampella, A.. - In: TETRAHEDRON. - ISSN 0040-4020. - 65:15(2009), pp. 2905-2909. [10.1016/j.tet.2009.02.016]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/351008
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