Numerous biologic processes and such diseases as cancer depend on activation of tyrosine kinase receptors. The RET tyrosine kinase receptor was discovered two decades ago as a transforming gene and was subsequently implicated in the formation of papillary and medullary thyroid carcinoma. This article examines the data about the mechanism of activation of downstream signal transduction pathways by RET oncoproteins. Collectively, these findings have advanced the understanding of the processes underlying thyroid carcinoma formation.
Dysregulated RET signaling in thyroid cancer / Castellone, M.; Santoro, Massimo. - In: ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA. - ISSN 0889-8529. - STAMPA. - 37:2(2008), pp. 363-374. [10.1016/j.ecl.2008.02.006]
Dysregulated RET signaling in thyroid cancer
SANTORO, MASSIMO
2008
Abstract
Numerous biologic processes and such diseases as cancer depend on activation of tyrosine kinase receptors. The RET tyrosine kinase receptor was discovered two decades ago as a transforming gene and was subsequently implicated in the formation of papillary and medullary thyroid carcinoma. This article examines the data about the mechanism of activation of downstream signal transduction pathways by RET oncoproteins. Collectively, these findings have advanced the understanding of the processes underlying thyroid carcinoma formation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
