The aims of this study were to detect Burkholderia cepacia complex (Bcc) strains in a cohort of Cystic Fibrosis patients (n=276) and to characterize Bcc isolates by molecular techniques. The results showed that 11.23% of patients were infected by Bcc. Burkholderia cenocepacia lineage III-A was the most prevalent species (64.3%) and, of these, 10% was cblA positive and 50% esmR positive. Less than half of the strains were sensitive to ceftazidime, meropenem, piperacillin tazobactam, and trimethoprim-sulfamethoxazole. About half of the strains (41%) had homogeneous profiles, suggesting cross-transmission. The infection by B. cenocepacia was associated to a high rate of mortality (p=0.01).
Burkholderia cepacia complex infection in a cohort of Italian patients with cystic fibrosis / Lambiase, Antonietta; Raia, Valeria; Stefani, S; Sepe, A; Ferri, P; Buonpensiero, P; Rossano, Fabio; Del Pezzo, M.. - In: JOURNAL OF MICROBIOLOGY. - ISSN 1225-8873. - STAMPA. - 45:3(2007), pp. 275-279.
Burkholderia cepacia complex infection in a cohort of Italian patients with cystic fibrosis.
LAMBIASE, ANTONIETTA;RAIA, VALERIA;Buonpensiero P;ROSSANO, FABIO;
2007
Abstract
The aims of this study were to detect Burkholderia cepacia complex (Bcc) strains in a cohort of Cystic Fibrosis patients (n=276) and to characterize Bcc isolates by molecular techniques. The results showed that 11.23% of patients were infected by Bcc. Burkholderia cenocepacia lineage III-A was the most prevalent species (64.3%) and, of these, 10% was cblA positive and 50% esmR positive. Less than half of the strains were sensitive to ceftazidime, meropenem, piperacillin tazobactam, and trimethoprim-sulfamethoxazole. About half of the strains (41%) had homogeneous profiles, suggesting cross-transmission. The infection by B. cenocepacia was associated to a high rate of mortality (p=0.01).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
