Continued investigation of cytotoxic extracts of the marine sponge Jaspis splendans has resulted in the discovery of jaspamides H–L (2–5). Their structures were determined by interpretation of their NMR and ESIMS data. All compounds exhibited potent cytotoxic activities and were shown to cause microfilament disruption. Biological activity and structural elucidation are reported here.
Jaspamides H-L, new actin-targeting depsipeptides from the sponge Jaspis splendans / F., Gala; D'Auria, MARIA VALERIA; DE MARINO, Simona; Sepe, Valentina; Zollo, Franco; C. D., Smith; J. E., Copper; Zampella, Angela. - In: TETRAHEDRON. - ISSN 0040-4020. - 64:30-31(2008), pp. 7127-7130. [10.1016/j.tet.2008.05.037]
Jaspamides H-L, new actin-targeting depsipeptides from the sponge Jaspis splendans
D'AURIA, MARIA VALERIA;DE MARINO, SIMONA;SEPE, VALENTINA;ZOLLO, FRANCO;ZAMPELLA, ANGELA
2008
Abstract
Continued investigation of cytotoxic extracts of the marine sponge Jaspis splendans has resulted in the discovery of jaspamides H–L (2–5). Their structures were determined by interpretation of their NMR and ESIMS data. All compounds exhibited potent cytotoxic activities and were shown to cause microfilament disruption. Biological activity and structural elucidation are reported here.| File | Dimensione | Formato | |
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