An efficient approach for the synthesis of cyclic peptides containing unnatural thioether side-chain bridges, based on the use of (2S)-9-fluorenylmethyl-2-[(tert-butoxycarbonyl)amino]-4-iodobutanoate and its homologue 5-iodopentanoate, is reported. The synthesis was performed by a tandem combination of solidphase peptide synthesis and microwave-assisted cyclization strategy
An efficient approach for monosulfide bridge formation in solid-phase peptide synthesis / Campiglia, P.; Gomez Monterrey, I.; Longobardo, Luigi; Lama, T.; Novellino, E.; Grieco, Paolo; GOMEZ MONTERREY, ISABEL MARIA. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - ELETTRONICO. - 45:(2004), pp. 1453-1456. [10.1016/j.tetlet.2003.12.036]
An efficient approach for monosulfide bridge formation in solid-phase peptide synthesis
LONGOBARDO, LUIGI;E. Novellino;GRIECO, PAOLO;GOMEZ MONTERREY, ISABEL MARIA
2004
Abstract
An efficient approach for the synthesis of cyclic peptides containing unnatural thioether side-chain bridges, based on the use of (2S)-9-fluorenylmethyl-2-[(tert-butoxycarbonyl)amino]-4-iodobutanoate and its homologue 5-iodopentanoate, is reported. The synthesis was performed by a tandem combination of solidphase peptide synthesis and microwave-assisted cyclization strategy| File | Dimensione | Formato | |
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