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EnglishWe suggest that the low MBL activity in patients bearing the HYPD haplotype may allow enhanced bacterial colonization of the gastric mucosa and reduce down-regulation of IL-1 beta production, thereby increasing the risk of gastric cancer. Otherwise, MBL2 HYPD haplotype may be in linkage disequilibrium with variants of other genes responsible for the increased risk of gastric cancer. To conclude, the MBL2-defective HYPD haplotype may be a novel genetic marker of risk for gastric cancer in Helicobacter pylori-infected patients.
| Titolo: | A mannose-binding lectin-defective haplotype is a risk factor for gastric cancer. | |
| Autori: | ||
| Data di pubblicazione: | 2006 | |
| Rivista: | ||
| Abstract: | We suggest that the low MBL activity in patients bearing the HYPD haplotype may allow enhanced ba...cterial colonization of the gastric mucosa and reduce down-regulation of IL-1 beta production, thereby increasing the risk of gastric cancer. Otherwise, MBL2 HYPD haplotype may be in linkage disequilibrium with variants of other genes responsible for the increased risk of gastric cancer. To conclude, the MBL2-defective HYPD haplotype may be a novel genetic marker of risk for gastric cancer in Helicobacter pylori-infected patients. | |
| Handle: | http://hdl.handle.net/11588/201998 | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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