In circulatory shock, melanocortins have life-saving effects likely to be mediated by MC4 receptors. To gain direct insight into the role of melanocortin MC4 receptors in haemorrhagic shock, we investigated the effects of two novel selective MC4 receptor agonists.
Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage / Giuliani, D.; Mioni, C.; Bazzani, C.; Zaffe, D.; Botticelli, A. R.; Capolongo, S.; Sabba, A.; Galantucci, M.; Iannone, A.; Grieco, Paolo; Novellino, Ettore; Colombo, G.; Tomasi, A.; Catania, A.; Guarini, S.. - In: BRITISH JOURNAL OF PHARMACOLOGY. - ISSN 0007-1188. - STAMPA. - 150:(2007), pp. 595-603. [10.1038/sj.bjp.0707115]
Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage
GRIECO, PAOLO;NOVELLINO, ETTORE;
2007
Abstract
In circulatory shock, melanocortins have life-saving effects likely to be mediated by MC4 receptors. To gain direct insight into the role of melanocortin MC4 receptors in haemorrhagic shock, we investigated the effects of two novel selective MC4 receptor agonists.| File | Dimensione | Formato | |
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