A series of about 70 secondary metabolites produced by marine organisms have been grouped into three structural types and discussed in terms of their reported antimalarial activities. The major groups of metabolites include isonitrile derivatives, alkaloids and cycloperoxide derivatives. Structure-activity relationships and, when applicable, mechanisms of action of the isolated molecules, have been discussed. The following discussion evidences that antimalarial marine molecules can efficiently integrate the panel of lead compounds isolated from terrestrial sources with new chemical backbones and, sometimes, with “typically marine” functional groups (as isonitriles)..
Antimalarial Lead Compound from Marine Organisms / Fattorusso, Ernesto; TAGLIALATELA SCAFATI, Orazio. - STAMPA. - 32:(2005), pp. 169-207.
Antimalarial Lead Compound from Marine Organisms
FATTORUSSO, ERNESTO;TAGLIALATELA SCAFATI, ORAZIO
2005
Abstract
A series of about 70 secondary metabolites produced by marine organisms have been grouped into three structural types and discussed in terms of their reported antimalarial activities. The major groups of metabolites include isonitrile derivatives, alkaloids and cycloperoxide derivatives. Structure-activity relationships and, when applicable, mechanisms of action of the isolated molecules, have been discussed. The following discussion evidences that antimalarial marine molecules can efficiently integrate the panel of lead compounds isolated from terrestrial sources with new chemical backbones and, sometimes, with “typically marine” functional groups (as isonitriles)..I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.