A modification of classical solid phase peptide synthesis methodol. under microwave irradn. was investigated. To illustrate the synthetic method a no. of Urotensin-II analogs contg. 2-fluoro-5-nitrobenzoic acid were prepd. A clear improvement in yield and reaction time using microwave heating in comparison with conventional thermal heating were obsd.
Rapid and Efficient Methodology to Perform Macrocyclization Reactions in Solid-Phase Peptide Chemistry / Grieco, Paolo; Campiglia, P.; GOMEZ MONTERREY, ISABEL MARIA; Lama, T.; Novellino, Ettore. - In: SYNLETT. - ISSN 0936-5214. - STAMPA. - 14:(2003), pp. 2216-2218. [10.1055/s-2003-42054]
Rapid and Efficient Methodology to Perform Macrocyclization Reactions in Solid-Phase Peptide Chemistry
GRIECO, PAOLO;GOMEZ MONTERREY, ISABEL MARIA;NOVELLINO, ETTORE
2003
Abstract
A modification of classical solid phase peptide synthesis methodol. under microwave irradn. was investigated. To illustrate the synthetic method a no. of Urotensin-II analogs contg. 2-fluoro-5-nitrobenzoic acid were prepd. A clear improvement in yield and reaction time using microwave heating in comparison with conventional thermal heating were obsd.| File | Dimensione | Formato | |
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