A liquid chromatography mass spectrometry (LC-MS) method is proposed for the sensitive, specific and direct detection of yessotoxin and its analogues, the marine biotoxins associated with diarrhetic shellfish poisoning (DSP) occurring in North Adriatic Sea since 1995. The LC-MS method provided a detection limit of 70 pg for yessotoxin in full scan mode and it was applied to determine toxic profile of a number of extracts or partially purified fractions of toxic mussels collected along Emilia Romagna coasts (Italy) in the period 1995-1999. Detection of a desulfo-yessotoxin derivative from Mytilus galloprovincialis collected in 1998 is also reported.
Direct detection of yessotoxin and its analogues by liquid chromatography coupled with electrospray ion trap mass spectrometry / Ciminiello, Patrizia; Dell'Aversano, Carmela; Fattorusso, Ernesto; Forino, Martino; S., Magno; R. P. O. L. E. T. T., I.. - In: JOURNAL OF CHROMATOGRAPHY A. - ISSN 0021-9673. - STAMPA. - 968:(2002), pp. 61-69. [10.1016/S0021-9673(02)00962-7]
Direct detection of yessotoxin and its analogues by liquid chromatography coupled with electrospray ion trap mass spectrometry
CIMINIELLO, PATRIZIA;DELL'AVERSANO, CARMELA;FATTORUSSO, ERNESTO;FORINO, MARTINO;
2002
Abstract
A liquid chromatography mass spectrometry (LC-MS) method is proposed for the sensitive, specific and direct detection of yessotoxin and its analogues, the marine biotoxins associated with diarrhetic shellfish poisoning (DSP) occurring in North Adriatic Sea since 1995. The LC-MS method provided a detection limit of 70 pg for yessotoxin in full scan mode and it was applied to determine toxic profile of a number of extracts or partially purified fractions of toxic mussels collected along Emilia Romagna coasts (Italy) in the period 1995-1999. Detection of a desulfo-yessotoxin derivative from Mytilus galloprovincialis collected in 1998 is also reported.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
