Encyclopedia of Cancer 1st Edition (2008)

http://www.springerlink.com/content/u2544p7368v26v60/accesso all'articolo. Prune H stands for the human homologue of the Drosophila prune gene. Prune protein was initially identified in Drosophila, in which its mutation caused a brownish-purple “prune” eye color due to significant loss of drosopterins “red pigments,” compared to the bright red eye of the wild-type fly, thus explaining its mutant name. Characteristics Prune is appertaining to the DHH family phosphoesterase proteins including RecJ DNA repair Exonucleases, Pyrophosphatases (PPASEs) and Exopolyphospatases (PPX). The DHH super-family can be divided into two main groups on the basis of a C-terminal motif that is very well conserved within each group, but not across the groups. All the members of this super-family possess four other motifs that contain highly conserved charged residues predicted to be responsible for binding ions and catalyzing the phosphoesterase reaction. The most characteristic of these is the third motif, with the signature DHH ....