Guanidine derivatives of ent-gomeric acids with antimicrobial properties and synergistic effect in combination therapy (Derivati guanidinici di acidi ent-gomerici con proprietà antimicrobiche e loro effetto sinergico in terapia combinata).

The invention relates to the chemistry of natural compounds and medicinal chemistry, in particular to compounds with a prenylated guanidine fragment, which have a wide range of antibacterial and antifungal properties. According to the invention, the use of ent-gomeroylguanidine and ent-13-epigomeroylguanidine as antibacterial and antifungal agents is claimed. The compounds showed high biological activity against gram-positive and gram-negative bacteria, as well as against strains of Candida albicans fungi. The use of these compounds as synergistic agents in combination antimicrobial therapy is also claimed.