Impact of Blood Flow and Vascular Integrity on Magnetic Thermal Ablation Efficacy in Tumor Treatment: A Computational Study

In this study, the authors investigate the influence of blood flow and vascular network integrity on the efficacy of thermal ablation therapies for tumor treatment. Utilizing computational simulations, the authors explored three scenarios: ablation without the heat sink effect of the vascular network, ablation with active blood flow, and ablation with vascular network damage. Results show that excluding the heat sink effect leads to a uniformly ablated tumor area with maximum temperatures reaching 48°C. Incorporating active blood flow demonstrates a significant cooling effect, preventing any thermal damage within 60 minutes. The third scenario reveals that vascular damage results in rapid temperature increases and asymmetrical ablation patterns. These findings highlight the critical role of blood flow dynamics and vascular integrity in determining the outcomes of thermal ablation. This study underscores the need for precise modeling of biological heat transfer processes to enhance the predictability and effectiveness of thermal therapies in oncological applications.