A cyclic 32-mer polymannoside, which represents the largest cyclic polysaccharide synthesized so far, was successfully constructed by a promoter-controlled cycloglycosylation approach under high-dilution conditions. Analysis of the cyclic 2-mer, 4-mer, 8-mer, 16-mer, and 32-mer mannosides by advanced NMR spectroscopy and computational studies indicated that the cyclic mannosides of various sizes adopted different conformational states and shapes.
Promoter‐Controlled Synthesis and Conformational Analysis of Cyclic Mannosides up to a 32‐mer / Li, Xiaona; Di Carluccio, Cristina; Miao, He; Zhang, Lvfeng; Shang, Jintao; Molinaro, Antonio; Xu, Peng; Silipo, Alba; Yu, Biao; Yang, You. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - 62:43(2023). [10.1002/anie.202307851]
Promoter‐Controlled Synthesis and Conformational Analysis of Cyclic Mannosides up to a 32‐mer
Di Carluccio, Cristina;Molinaro, Antonio;Silipo, Alba
;
2023
Abstract
A cyclic 32-mer polymannoside, which represents the largest cyclic polysaccharide synthesized so far, was successfully constructed by a promoter-controlled cycloglycosylation approach under high-dilution conditions. Analysis of the cyclic 2-mer, 4-mer, 8-mer, 16-mer, and 32-mer mannosides by advanced NMR spectroscopy and computational studies indicated that the cyclic mannosides of various sizes adopted different conformational states and shapes.| File | Dimensione | Formato | |
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