There arefewclinicalreportsofmelanomasinreptiles.A10-year-oldmalered-footedtortoise(Chelonoidis carbo- naria) wasreferredtotheVeterinaryHospitalpresentingwithanulceratedmassinthelateralaspectoftheleft pelvic limb.Radiographsdemonstratedswellingandincreasedsofttissuedensityoverlyingthefemur,tibia,and fibula, withoutboneinvolvement.Fine-needleaspirationcytologyrevealedinnumerableroundcells,witha defined cytoplasm filled with fine brown-blackgranules(melanin),whichwereconsideredwell-differentiated melanocytes, suggestingacaseofcutaneousmelanoma.Themasswassurgicallyremoved.Itwasencapsulated and hadanabundantbloodsupply.Histopathologicalexaminationrevealedawelldemarcatedandencapsulated neoplastic proliferationofmesenchymalcells,withhighcellularityandmoderate fibrous stroma.Lymphangiecta- sia inthedermisadjacenttothetumorwasalsoobserved.Immunohistochemistryconfirmed thediagnosis,with cells stainingpositiveforMelan-Aantibodybeingobservedinneoplasticproliferation,adjacentdermis,inside lymphatic vessels,andinvadingthedelimitingtumor’s capsule.Therewasnoevidenceoflocalorsystemicrecur- rence oftheneoplasmover500daysafterremoval.Chelonianscanbeaffectedbycutaneousmelanomas.Surgical removal inthiscasewascurative.
Cutaneous melanoma in a red-footed tortoise (Chelonoidis carbonaria) / De Santi, Mariele; Cruz, Nathan; Barranco, Guilherme; Lima, Gabriela; Menezes, Mareliza; Sierramatiz, Oscar; Freitas, Pamela; Atie, Laura; Armani, Daniela; Santana, Aureo; Vasconcelos, Rosemeri; Werther, Karin. - In: JOURNAL OF EXOTIC PET MEDICINE. - ISSN 1557-5063. - 34:(2020), pp. 44-47. [10.1053/j.jepm.2020.03.017]
Cutaneous melanoma in a red-footed tortoise (Chelonoidis carbonaria)
Mariele De Santi
;
2020
Abstract
There arefewclinicalreportsofmelanomasinreptiles.A10-year-oldmalered-footedtortoise(Chelonoidis carbo- naria) wasreferredtotheVeterinaryHospitalpresentingwithanulceratedmassinthelateralaspectoftheleft pelvic limb.Radiographsdemonstratedswellingandincreasedsofttissuedensityoverlyingthefemur,tibia,and fibula, withoutboneinvolvement.Fine-needleaspirationcytologyrevealedinnumerableroundcells,witha defined cytoplasm filled with fine brown-blackgranules(melanin),whichwereconsideredwell-differentiated melanocytes, suggestingacaseofcutaneousmelanoma.Themasswassurgicallyremoved.Itwasencapsulated and hadanabundantbloodsupply.Histopathologicalexaminationrevealedawelldemarcatedandencapsulated neoplastic proliferationofmesenchymalcells,withhighcellularityandmoderate fibrous stroma.Lymphangiecta- sia inthedermisadjacenttothetumorwasalsoobserved.Immunohistochemistryconfirmed thediagnosis,with cells stainingpositiveforMelan-Aantibodybeingobservedinneoplasticproliferation,adjacentdermis,inside lymphatic vessels,andinvadingthedelimitingtumor’s capsule.Therewasnoevidenceoflocalorsystemicrecur- rence oftheneoplasmover500daysafterremoval.Chelonianscanbeaffectedbycutaneousmelanomas.Surgical removal inthiscasewascurative.| File | Dimensione | Formato | |
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