Introduction: New potential biomarkers to pre-intervention identification of a clinically significant prostate cancer (csPCa) will prevent overdiagnosis and overtreatment and limit quality of life impairment of PCa patients. Areas covered: We have developed a comprehensive review focusing our research on the increasing knowledge of the role of SelectMDX® in csPCa detection. Areas identified as clinically relevant are the ability of SelectMDX® to predict csPCa in active surveillance setting, its predictive ability when combined with multiparametric MRI and the role of SelectMDX® in the landscape of urinary biomarkers. Expert opinion: Several PCa biomarkers have been developed either alone or in combination with clinical variables to improve csPCa detection. SelectMDX® score includes genomic markers, age, PSA, prostate volume, and digital rectal examination. Several studies have shown consistency in the ability to improve detection of csPCa, avoidance of unnecessary prostate biopsies, helpful in decision-making for clinical benefit of PCa patients with future well designed, and impactful studies.

Beyond blood biomarkers: the role of SelectMDX in clinically significant prostate cancer identification / Ferro, Matteo; Rocco, Bernardo; Maggi, Martina; Lucarelli, Giuseppe; Falagario, Ugo Giovanni; Del Giudice, Francesco; Crocetto, Felice; Barone, Biagio; La Civita, Evelina; Lasorsa, Francesco; Brescia, Antonio; Catellani, Michele; Busetto, Gian Maria; Tataru, Octavian Sabin; Terracciano, Daniela. - In: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS. - ISSN 1744-8352. - 23:12(2023). [10.1080/14737159.2023.2277366]

Beyond blood biomarkers: the role of SelectMDX in clinically significant prostate cancer identification

Ferro, Matteo;Crocetto, Felice;Barone, Biagio;La Civita, Evelina;Brescia, Antonio;Terracciano, Daniela
2023

Abstract

Introduction: New potential biomarkers to pre-intervention identification of a clinically significant prostate cancer (csPCa) will prevent overdiagnosis and overtreatment and limit quality of life impairment of PCa patients. Areas covered: We have developed a comprehensive review focusing our research on the increasing knowledge of the role of SelectMDX® in csPCa detection. Areas identified as clinically relevant are the ability of SelectMDX® to predict csPCa in active surveillance setting, its predictive ability when combined with multiparametric MRI and the role of SelectMDX® in the landscape of urinary biomarkers. Expert opinion: Several PCa biomarkers have been developed either alone or in combination with clinical variables to improve csPCa detection. SelectMDX® score includes genomic markers, age, PSA, prostate volume, and digital rectal examination. Several studies have shown consistency in the ability to improve detection of csPCa, avoidance of unnecessary prostate biopsies, helpful in decision-making for clinical benefit of PCa patients with future well designed, and impactful studies.
2023
Beyond blood biomarkers: the role of SelectMDX in clinically significant prostate cancer identification / Ferro, Matteo; Rocco, Bernardo; Maggi, Martina; Lucarelli, Giuseppe; Falagario, Ugo Giovanni; Del Giudice, Francesco; Crocetto, Felice; Barone, Biagio; La Civita, Evelina; Lasorsa, Francesco; Brescia, Antonio; Catellani, Michele; Busetto, Gian Maria; Tataru, Octavian Sabin; Terracciano, Daniela. - In: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS. - ISSN 1744-8352. - 23:12(2023). [10.1080/14737159.2023.2277366]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/961417
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