Macrophages and endothelial cells (ECs) have essential roles in physiological and pathological conditions by regulating inflammation, vascularization and tissue remodelling. Although the interactions between macrophages and ECs in tissue homeostasis and disease progression have been extensively studied in the past few decades, the role of the extracellular matrix in this intercellular process is less known. Here, we review the current knowledge on how microenvironmental cues, biophysical and biochemical, dictate macrophage–endothelium crosstalk in the pathology of different diseases. We summarize studies using biomaterials as extracellular matrix with tenable properties to manipulate macrophage–EC fate to regulate innate and adaptive immunity, angiogenesis and regeneration. Finally, we discuss the potential and challenges of developing novel therapeutic strategies to tailor macrophage–EC niches to restore homeostasis in various diseases. © 2023, Springer Nature Limited.
Engineering biomaterials to tailor the microenvironment for macrophage–endothelium interactions / Guan, Ya; Racioppi, Luigi; Gerecht, Sharon. - In: NATURE REVIEWS. MATERIALS. - ISSN 2058-8437. - 8:10(2023), pp. 688-699. [10.1038/s41578-023-00591-9]
Engineering biomaterials to tailor the microenvironment for macrophage–endothelium interactions
Racioppi, LuigiSecondo
Membro del Collaboration Group
;
2023
Abstract
Macrophages and endothelial cells (ECs) have essential roles in physiological and pathological conditions by regulating inflammation, vascularization and tissue remodelling. Although the interactions between macrophages and ECs in tissue homeostasis and disease progression have been extensively studied in the past few decades, the role of the extracellular matrix in this intercellular process is less known. Here, we review the current knowledge on how microenvironmental cues, biophysical and biochemical, dictate macrophage–endothelium crosstalk in the pathology of different diseases. We summarize studies using biomaterials as extracellular matrix with tenable properties to manipulate macrophage–EC fate to regulate innate and adaptive immunity, angiogenesis and regeneration. Finally, we discuss the potential and challenges of developing novel therapeutic strategies to tailor macrophage–EC niches to restore homeostasis in various diseases. © 2023, Springer Nature Limited.File | Dimensione | Formato | |
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