Introduction: Acute kidney disease and chronic kidney disease are considered conditions that can increase the mortality and severity of COVID-19. However, few studies have investigated the impact of creatinine levels on COVID-19 progression in patients without a history of chronic kidney disease. The aim of the study was to assess the impact of creatinine levels at hospital admission on COVID-19 progression and mortality. Methods: We performed a multicenter, observational, retrospective study involving seventeen COVID-19 Units in the Campania region in southern Italy. All adult (≥18 years) patients, hospitalized with a diagnosis of SARS-CoV-2 infection confirmed by a positive reverse transcriptase-polymerase chain reaction on a naso-oropharyngeal swab, from 28 February 2020 to 31 May 2021, were enrolled in the CoviCamp cohort. Results: Evaluating inclusion/exclusion criteria, 1357 patients were included. Considering in-hospital mortality and creatinine value at admission, the best cut-off point to discriminate a death during hospitalization was 1.115 mg/dL. The logistic regression demonstrated that factors independently associated with mortality were age (OR 1.082, CI: 1.054-1.110), Charlson Comorbidity Index (CCI) (OR 1.341, CI: 1.178-1.526), and an abnormal creatinine value at admission, defined as equal to or above 1.12 mg/dL (OR 2.233, CI: 1.373-3.634). Discussion: In conclusion, our study is in line with previous studies confirming that the creatinine serum level can predict mortality in COVID-19 patients and defining that the best cut-off of the creatinine serum level at admission to predict mortality was 1.12 mg/dL.

Prognostic Value of Creatinine Levels at Admission on Disease Progression and Mortality in Patients with COVID-19—An Observational Retrospective Study / Russo, Antonio; Pisaturo, Mariantonietta; Monari, Caterina; Ciminelli, Federica; Maggi, Paolo; Allegorico, Enrico; Gentile, Ivan; Sangiovanni, Vincenzo; Esposito, Vincenzo; Gentile, Valeria; Calabria, Giosuele; Pisapia, Raffaella; Carriero, Canio; Masullo, Alfonso; Manzillo, Elio; Russo, Grazia; Parrella, Roberto; Dell’Aquila, Giuseppina; Gambardella, Michele; Ponticiello, Antonio; Onorato, Lorenzo; Coppola, Nicola. - In: PATHOGENS. - ISSN 2076-0817. - 12:8(2023). [10.3390/pathogens12080973]

Prognostic Value of Creatinine Levels at Admission on Disease Progression and Mortality in Patients with COVID-19—An Observational Retrospective Study

Caterina Monari;Paolo MAGGI;Ivan Gentile;Grazia Russo;Roberto Parrella;Michele Gambardella;Antonio PONTICIELLO;Lorenzo Onorato;Nicola Coppola
2023

Abstract

Introduction: Acute kidney disease and chronic kidney disease are considered conditions that can increase the mortality and severity of COVID-19. However, few studies have investigated the impact of creatinine levels on COVID-19 progression in patients without a history of chronic kidney disease. The aim of the study was to assess the impact of creatinine levels at hospital admission on COVID-19 progression and mortality. Methods: We performed a multicenter, observational, retrospective study involving seventeen COVID-19 Units in the Campania region in southern Italy. All adult (≥18 years) patients, hospitalized with a diagnosis of SARS-CoV-2 infection confirmed by a positive reverse transcriptase-polymerase chain reaction on a naso-oropharyngeal swab, from 28 February 2020 to 31 May 2021, were enrolled in the CoviCamp cohort. Results: Evaluating inclusion/exclusion criteria, 1357 patients were included. Considering in-hospital mortality and creatinine value at admission, the best cut-off point to discriminate a death during hospitalization was 1.115 mg/dL. The logistic regression demonstrated that factors independently associated with mortality were age (OR 1.082, CI: 1.054-1.110), Charlson Comorbidity Index (CCI) (OR 1.341, CI: 1.178-1.526), and an abnormal creatinine value at admission, defined as equal to or above 1.12 mg/dL (OR 2.233, CI: 1.373-3.634). Discussion: In conclusion, our study is in line with previous studies confirming that the creatinine serum level can predict mortality in COVID-19 patients and defining that the best cut-off of the creatinine serum level at admission to predict mortality was 1.12 mg/dL.
2023
Prognostic Value of Creatinine Levels at Admission on Disease Progression and Mortality in Patients with COVID-19—An Observational Retrospective Study / Russo, Antonio; Pisaturo, Mariantonietta; Monari, Caterina; Ciminelli, Federica; Maggi, Paolo; Allegorico, Enrico; Gentile, Ivan; Sangiovanni, Vincenzo; Esposito, Vincenzo; Gentile, Valeria; Calabria, Giosuele; Pisapia, Raffaella; Carriero, Canio; Masullo, Alfonso; Manzillo, Elio; Russo, Grazia; Parrella, Roberto; Dell’Aquila, Giuseppina; Gambardella, Michele; Ponticiello, Antonio; Onorato, Lorenzo; Coppola, Nicola. - In: PATHOGENS. - ISSN 2076-0817. - 12:8(2023). [10.3390/pathogens12080973]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/956226
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