A hybrid plasmonic transducer made of a Poly-(ethylene glycol) diacrylate (PEGDA) hydrogel and citrate gold nanoparticles detects the biotin-streptavidin interaction at picomolar (× 10-12 m) concentrations. The all-solution fabrication strategy, herein proposed, is large-scale, easily tunable, and low-cost; nevertheless, this innovative device is highly reproducible and optically stable, and it can be used in dual-optical mode. Indeed, both metal-enhanced fluorescence and localized surface plasmon resonance signals can be exploited to quantify the biorecognition process in a 3D architecture. The large swelling capability of high molecular weight PEGDA is used to investigate the plasmon absorption variations resulting from the exposure to biological solutions containing high molecular weight molecules within the 3D network. The proposed transducer represents a low-cost, flexible, and easy-to-use platform for sensing applications in biomedical or environmental diagnostics.

H3 (Hydrogel-Based, High-Sensitivity, Hybrid) Plasmonic Transducers for Biomolecular Interactions Monitoring / Miranda, B.; Moretta, R.; Dardano, P.; Rea, I.; Forestiere, C.; De Stefano, L.. - In: ADVANCED MATERIALS TECHNOLOGIES. - ISSN 2365-709X. - 7:9(2022). [10.1002/admt.202101425]

H3 (Hydrogel-Based, High-Sensitivity, Hybrid) Plasmonic Transducers for Biomolecular Interactions Monitoring

Miranda B.;Moretta R.;Dardano P.;Rea I.;Forestiere C.;De Stefano L.
2022

Abstract

A hybrid plasmonic transducer made of a Poly-(ethylene glycol) diacrylate (PEGDA) hydrogel and citrate gold nanoparticles detects the biotin-streptavidin interaction at picomolar (× 10-12 m) concentrations. The all-solution fabrication strategy, herein proposed, is large-scale, easily tunable, and low-cost; nevertheless, this innovative device is highly reproducible and optically stable, and it can be used in dual-optical mode. Indeed, both metal-enhanced fluorescence and localized surface plasmon resonance signals can be exploited to quantify the biorecognition process in a 3D architecture. The large swelling capability of high molecular weight PEGDA is used to investigate the plasmon absorption variations resulting from the exposure to biological solutions containing high molecular weight molecules within the 3D network. The proposed transducer represents a low-cost, flexible, and easy-to-use platform for sensing applications in biomedical or environmental diagnostics.
2022
H3 (Hydrogel-Based, High-Sensitivity, Hybrid) Plasmonic Transducers for Biomolecular Interactions Monitoring / Miranda, B.; Moretta, R.; Dardano, P.; Rea, I.; Forestiere, C.; De Stefano, L.. - In: ADVANCED MATERIALS TECHNOLOGIES. - ISSN 2365-709X. - 7:9(2022). [10.1002/admt.202101425]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/954497
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