A copper-(I)-catalyzed variation of the Huisgen 1,3-dipolar cycloaddition has been applied to lead the in living-cell mass-spectrometry based identification of protein targets of oleocanthal, a natural metabolite daily ingested by millions of people. Chemical proteomics revealed heat-shock proteins, HSP70 and HSP90, as main oleocanthal interactors in living systems. These two proteins are involved in cancer development and, thus, our findings could have important outcomes for a deep evaluation of the bio-pharmacological significance of oleocanthal.
In Cell Interactome of Oleocanthal, an Extra Virgin Olive Oil Bioactive Component / Cassiano, Chiara; Casapullo, Agostino; Tosco, Alessandra; Monti, Maria Chiara; Riccio, Raffaele. - In: NATURAL PRODUCT COMMUNICATIONS. - ISSN 1934-578X. - 10:(2015), pp. 1013-1016.
In Cell Interactome of Oleocanthal, an Extra Virgin Olive Oil Bioactive Component
CASSIANO, CHIARA;CASAPULLO, Agostino;TOSCO, ALESSANDRA;MONTI, Maria Chiara;RICCIO, Raffaele
2015
Abstract
A copper-(I)-catalyzed variation of the Huisgen 1,3-dipolar cycloaddition has been applied to lead the in living-cell mass-spectrometry based identification of protein targets of oleocanthal, a natural metabolite daily ingested by millions of people. Chemical proteomics revealed heat-shock proteins, HSP70 and HSP90, as main oleocanthal interactors in living systems. These two proteins are involved in cancer development and, thus, our findings could have important outcomes for a deep evaluation of the bio-pharmacological significance of oleocanthal.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
