A bio-orthogonal click-chemistry procedure was developed to allow the in cell interactome profiling of scalaradial, an anti-inflammatory marine natural product. The results were validated through the application of the classical in vitro chemical proteomics and several bio-physical methods; peroxiredoxins, 14-3-3 isoforms and proteasomes were recognized as main scalaradial targets
In cell scalaradial interactome profiling using a bio-orthogonal clickable probe / Cassiano, Chiara; Margarucci, Luigi; Esposito, Roberta; Riccio, Raffaele; Tosco, Alessandra; Casapullo, Agostino; Monti, Maria Chiara. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 50:(2014), pp. 6043-6045. [10.1039/c4cc00989d]
In cell scalaradial interactome profiling using a bio-orthogonal clickable probe
CASSIANO, CHIARA;RICCIO, Raffaele;TOSCO, ALESSANDRA;CASAPULLO, Agostino;MONTI, Maria Chiara
2014
Abstract
A bio-orthogonal click-chemistry procedure was developed to allow the in cell interactome profiling of scalaradial, an anti-inflammatory marine natural product. The results were validated through the application of the classical in vitro chemical proteomics and several bio-physical methods; peroxiredoxins, 14-3-3 isoforms and proteasomes were recognized as main scalaradial targets| File | Dimensione | Formato | |
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