The complex nucleoprotein landscape of the eukaryotic cell nucleus is rich in dynamic proteins that lack a stable three-dimensional structure. Many of these intrinsically disordered proteins operate directly on the first fundamental level of genome compaction: the nucleosome. Here we give an overview of how disordered interactions with and within nucleosomes shape the dynamics, architecture, and epigenetic regulation of the genetic material, controlling cellular transcription patterns. We highlight experimental and computational challenges in the study of protein disorder and illustrate how integrative approaches are increasingly unveiling the fine details of nuclear interaction networks. We finally dissect sequence properties encoded in disordered regions and assess common features of disordered nucleosome-binding proteins. As drivers of many critical biological processes, disordered proteins are integral to a comprehensive molecular view of the dynamic nuclear milieu. ZR 0
Protein intrinsic disorder on a dynamic nucleosomal landscape / Bjarnason, Sveinn; Ruidiaz Sarah, F.; Mcivor, Jordan; Mercadante, D; Heidarssona Petur, O.. - In: PROGRESS IN MOLECULAR BIOLOGY AND TRANSLATIONAL SCIENCE. - ISSN 1877-1173. - 183:(2021), pp. 295-354. [10.1016/bs.pmbts.2021.06.006]
Protein intrinsic disorder on a dynamic nucleosomal landscape
Mercadante D;
2021
Abstract
The complex nucleoprotein landscape of the eukaryotic cell nucleus is rich in dynamic proteins that lack a stable three-dimensional structure. Many of these intrinsically disordered proteins operate directly on the first fundamental level of genome compaction: the nucleosome. Here we give an overview of how disordered interactions with and within nucleosomes shape the dynamics, architecture, and epigenetic regulation of the genetic material, controlling cellular transcription patterns. We highlight experimental and computational challenges in the study of protein disorder and illustrate how integrative approaches are increasingly unveiling the fine details of nuclear interaction networks. We finally dissect sequence properties encoded in disordered regions and assess common features of disordered nucleosome-binding proteins. As drivers of many critical biological processes, disordered proteins are integral to a comprehensive molecular view of the dynamic nuclear milieu. ZR 0I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.