LL-III is a natural anticancer peptide able to cross the membrane of cancer cells and to localize in the nucleolus, but its intracellular target is unknown. Here, we show that LL-III is able to bind with nM affinity to specific G-quadruplex structures known to be relevant anticancer targets.
The anticancer peptide LL-III binds with nanomolar affinity to human telomeric and cMyc G-quadruplexes / Campanile, M.; Oliva, R.; Del Vecchio, P.; Winter, R.; Petraccone, L.. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 59:41(2023), pp. 6179-6182. [10.1039/d3cc00737e]
The anticancer peptide LL-III binds with nanomolar affinity to human telomeric and cMyc G-quadruplexes
Campanile M.;Oliva R.;Del Vecchio P.;Petraccone L.
2023
Abstract
LL-III is a natural anticancer peptide able to cross the membrane of cancer cells and to localize in the nucleolus, but its intracellular target is unknown. Here, we show that LL-III is able to bind with nM affinity to specific G-quadruplex structures known to be relevant anticancer targets.File in questo prodotto:
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