studyThe prevalence of metabolic syndrome and its hepaticcomponent — non-alcoholic fatty liver disease (NAFLD) —has increased alarmingly, paralleling the worldwide obe-sity epidemics. The pathophysiology of NAFLD is not clearlyunderstood, but it has been proposed to be the result ofmultiple ‘‘hits’’. A number of studies increasingly sup-ports the pathogenetic role also of the gut microbiota (GM)both in NAFLD onset and progression. In this respect, GMwould exert its noxious effects through the dysfunction ofthe gut-liver axis (GLA), which includes some or all of the fol-lowing components: increased intestinal permeability (IP),endogenous ethanol (ETOH) and systemic endotoxin (LPS)concentrations. We studied 10 Ob Italian children, consecutivelyrecruited at our center after parental agreement and writ-ten informed consent. The inclusion criteria were age 8—13years, and a body mass index (BMI) > 97th percentile. Sixnon-Ob and non-overweight (BMI < 85th percentile), healthynormal-weight (NW) controls with normal anthropomet-ric, clinical, laboratory and ultrasonographic (US) hepaticparameters and no other associated diseases were recruitedamong patients of the Pediatric Surgery Section listed forelective minor surgery.

Relations of gut liver axis components and gut microbiota in obese children with fatty liver: A pilot study / Pierri, Luca; Saggese, Pasquale; GUERCIO NUZIO, Salvatore; Troisi, Jacopo; DI STASI, Martina; Poeta, Marco; Savastano, Riccardo; Marchese, Giovanna; Tarallo, Roberta; Massa, Grazia; Ciccone, Vincenzo; Ziegenhardt, Doreen; Cavallo, Pierpaolo; Bergheim, Ina; Weisz, Alessandro; Vajro, Pietro. - In: CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY. - ISSN 2210-7401. - 42:4(2018), pp. 387-390. [10.1016/j.clinre.2018.03.015]

Relations of gut liver axis components and gut microbiota in obese children with fatty liver: A pilot study

GUERCIO NUZIO, SALVATORE;DI STASI, MARTINA;POETA, MARCO;MARCHESE, GIOVANNA;Weisz, Alessandro;VAJRO, Pietro
2018

Abstract

studyThe prevalence of metabolic syndrome and its hepaticcomponent — non-alcoholic fatty liver disease (NAFLD) —has increased alarmingly, paralleling the worldwide obe-sity epidemics. The pathophysiology of NAFLD is not clearlyunderstood, but it has been proposed to be the result ofmultiple ‘‘hits’’. A number of studies increasingly sup-ports the pathogenetic role also of the gut microbiota (GM)both in NAFLD onset and progression. In this respect, GMwould exert its noxious effects through the dysfunction ofthe gut-liver axis (GLA), which includes some or all of the fol-lowing components: increased intestinal permeability (IP),endogenous ethanol (ETOH) and systemic endotoxin (LPS)concentrations. We studied 10 Ob Italian children, consecutivelyrecruited at our center after parental agreement and writ-ten informed consent. The inclusion criteria were age 8—13years, and a body mass index (BMI) > 97th percentile. Sixnon-Ob and non-overweight (BMI < 85th percentile), healthynormal-weight (NW) controls with normal anthropomet-ric, clinical, laboratory and ultrasonographic (US) hepaticparameters and no other associated diseases were recruitedamong patients of the Pediatric Surgery Section listed forelective minor surgery.
2018
Relations of gut liver axis components and gut microbiota in obese children with fatty liver: A pilot study / Pierri, Luca; Saggese, Pasquale; GUERCIO NUZIO, Salvatore; Troisi, Jacopo; DI STASI, Martina; Poeta, Marco; Savastano, Riccardo; Marchese, Giovanna; Tarallo, Roberta; Massa, Grazia; Ciccone, Vincenzo; Ziegenhardt, Doreen; Cavallo, Pierpaolo; Bergheim, Ina; Weisz, Alessandro; Vajro, Pietro. - In: CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY. - ISSN 2210-7401. - 42:4(2018), pp. 387-390. [10.1016/j.clinre.2018.03.015]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/944272
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