Objectives: The study measures trends in the profile of patients with chronic hepatitis B virus linked to care in Italy. Methods: A cross-sectional, multicenter, observational cohort (PITER cohort) of consecutive patients with hepatitis B surface antigen (HBsAg) over the period 2019-2021 from 46 centers was evaluated. The reference was the MASTER cohort collected over the years 2012-2015. Standard statistical methods were used. Results: The PITER cohort enrolled 4583 patients, of whom 21.8% were non-Italian natives. Compared with those in MASTER, the patients were older and more often female. The prevalence of hepatitis B e antigen (HBeAg) declined (7.2% vs 12.3; P <0.0001) and that of anti-hepatitis D virus (HDV) remained stable (9.3% vs 8.3%). In both cohorts, about 25% of the patients had cirrhosis, and those in the PITER cohort were older. HBeAg-positive was 5.0% vs 12.6% (P <0.0001) and anti-HDV positive 24.8% vs 17.5% (P <0.0017). In the logistic model, the variables associated with cirrhosis were anti-HDV-positive (odds ratio = 10.08; confidence interval 7.63-13.43), age, sex, and body mass index; the likelihood of cirrhosis was reduced by 40% in the PITER cohort. Among non-Italians, 12.3% were HBeAg-positive (vs 23.4% in the MASTER cohort; P <0.0001), and 12.3% were anti-HDV-positive (vs 11.1%). Overall, the adherence to the European Association for the Study of the Liver recommendations for antiviral treatment increased over time. Conclusion: Chronic hepatitis B virus infection appears to be in the process of becoming under control in Italy; however, HDV infection is still a health concern in patients with cirrhosis and in migrants.

Trends in chronic hepatitis B virus infection in Italy over a 10-year period: Clues from the nationwide PITER and MASTER cohorts toward elimination / Brancaccio, Giuseppina; Coco, Barbara; Nardi, Alessandra; Quaranta, Maria Giovanna; Tosti, Maria Elena; Ferrigno, Luigina; Cacciola, Irene; Messina, Vincenzo; Chessa, Luchino; Morisco, Filomena; Milella, Michele; Barbaro, Francesco; Ciancio, Alessia; Russo, Francesco Paolo; Coppola, Nicola; Blanc, Pierluigi; Claar, Ernesto; Verucchi, Gabriella; Puoti, Massimo; Zignego, Anna Linda; Chemello, Liliana; Madonia, Salvatore; Fagiuoli, Stefano; Marzano, Alfredo; Ferrari, Carlo; Lampertico, Pietro; Di Marco, Vito; Craxì, Antonio; Santantonio, Teresa Antonia; Raimondo, Giovanni; Brunetto, Maurizia R; Gaeta, Giovanni Battista; Kondili, Loreta A. - In: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. - ISSN 1878-3511. - 129:(2023), pp. 266-273. [10.1016/j.ijid.2023.02.006]

Trends in chronic hepatitis B virus infection in Italy over a 10-year period: Clues from the nationwide PITER and MASTER cohorts toward elimination

Morisco, Filomena;Barbaro, Francesco;Russo, Francesco Paolo;Coppola, Nicola;
2023

Abstract

Objectives: The study measures trends in the profile of patients with chronic hepatitis B virus linked to care in Italy. Methods: A cross-sectional, multicenter, observational cohort (PITER cohort) of consecutive patients with hepatitis B surface antigen (HBsAg) over the period 2019-2021 from 46 centers was evaluated. The reference was the MASTER cohort collected over the years 2012-2015. Standard statistical methods were used. Results: The PITER cohort enrolled 4583 patients, of whom 21.8% were non-Italian natives. Compared with those in MASTER, the patients were older and more often female. The prevalence of hepatitis B e antigen (HBeAg) declined (7.2% vs 12.3; P <0.0001) and that of anti-hepatitis D virus (HDV) remained stable (9.3% vs 8.3%). In both cohorts, about 25% of the patients had cirrhosis, and those in the PITER cohort were older. HBeAg-positive was 5.0% vs 12.6% (P <0.0001) and anti-HDV positive 24.8% vs 17.5% (P <0.0017). In the logistic model, the variables associated with cirrhosis were anti-HDV-positive (odds ratio = 10.08; confidence interval 7.63-13.43), age, sex, and body mass index; the likelihood of cirrhosis was reduced by 40% in the PITER cohort. Among non-Italians, 12.3% were HBeAg-positive (vs 23.4% in the MASTER cohort; P <0.0001), and 12.3% were anti-HDV-positive (vs 11.1%). Overall, the adherence to the European Association for the Study of the Liver recommendations for antiviral treatment increased over time. Conclusion: Chronic hepatitis B virus infection appears to be in the process of becoming under control in Italy; however, HDV infection is still a health concern in patients with cirrhosis and in migrants.
2023
Trends in chronic hepatitis B virus infection in Italy over a 10-year period: Clues from the nationwide PITER and MASTER cohorts toward elimination / Brancaccio, Giuseppina; Coco, Barbara; Nardi, Alessandra; Quaranta, Maria Giovanna; Tosti, Maria Elena; Ferrigno, Luigina; Cacciola, Irene; Messina, Vincenzo; Chessa, Luchino; Morisco, Filomena; Milella, Michele; Barbaro, Francesco; Ciancio, Alessia; Russo, Francesco Paolo; Coppola, Nicola; Blanc, Pierluigi; Claar, Ernesto; Verucchi, Gabriella; Puoti, Massimo; Zignego, Anna Linda; Chemello, Liliana; Madonia, Salvatore; Fagiuoli, Stefano; Marzano, Alfredo; Ferrari, Carlo; Lampertico, Pietro; Di Marco, Vito; Craxì, Antonio; Santantonio, Teresa Antonia; Raimondo, Giovanni; Brunetto, Maurizia R; Gaeta, Giovanni Battista; Kondili, Loreta A. - In: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. - ISSN 1878-3511. - 129:(2023), pp. 266-273. [10.1016/j.ijid.2023.02.006]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/933857
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