: Life sustains itself using energy generated by thermodynamic disequilibria, commonly existing as redox disequilibria. Metals are significant players in controlling redox reactions, as they are essential components of the engine that life uses to tap into the thermodynamic disequilibria necessary for metabolism. The number of proteins that evolved to catalyze redox reactions is extraordinary, as is the diversification level of metal cofactors and catalytic domain structures involved. Notwithstanding the importance of the topic, the relationship between metals and the redox reactions they are involved in has been poorly explored. This work reviews the structure and function of different prokaryotic organometallic-protein complexes, highlighting their pivotal role in controlling biogeochemistry. We focus on a specific subset of metal-containing oxidoreductases (EC1 or EC7.1), which are directly involved in biogeochemical cycles, i.e., at least one substrate or product is a small inorganic molecule that is or can be exchanged with the environment. Based on these inclusion criteria, we select and report 59 metalloenzymes, describing the organometallic structure of their active sites, the redox reactions in which they are involved, and their biogeochemical roles.

Oxidoreductases and metal cofactors in the functioning of the earth / Hay Mele, Bruno; Monticelli, Maria; Leone, Serena; Bastoni, Deborah; Barosa, Bernardo; Cascone, Martina; Migliaccio, Flavia; Montemagno, Francesco; Ricciardelli, Annarita; Tonietti, Luca; Rotundi, Alessandra; Cordone, Angelina; Giovannelli, Donato. - In: ESSAYS IN BIOCHEMISTRY. - ISSN 0071-1365. - (2023). [10.1042/EBC20230012]

Oxidoreductases and metal cofactors in the functioning of the earth

Hay Mele, Bruno
Primo
;
Monticelli, Maria
Secondo
;
Bastoni, Deborah;Barosa, Bernardo;Cascone, Martina;Migliaccio, Flavia;Montemagno, Francesco;Ricciardelli, Annarita;Tonietti, Luca;Cordone, Angelina
Penultimo
;
Giovannelli, Donato
Ultimo
2023

Abstract

: Life sustains itself using energy generated by thermodynamic disequilibria, commonly existing as redox disequilibria. Metals are significant players in controlling redox reactions, as they are essential components of the engine that life uses to tap into the thermodynamic disequilibria necessary for metabolism. The number of proteins that evolved to catalyze redox reactions is extraordinary, as is the diversification level of metal cofactors and catalytic domain structures involved. Notwithstanding the importance of the topic, the relationship between metals and the redox reactions they are involved in has been poorly explored. This work reviews the structure and function of different prokaryotic organometallic-protein complexes, highlighting their pivotal role in controlling biogeochemistry. We focus on a specific subset of metal-containing oxidoreductases (EC1 or EC7.1), which are directly involved in biogeochemical cycles, i.e., at least one substrate or product is a small inorganic molecule that is or can be exchanged with the environment. Based on these inclusion criteria, we select and report 59 metalloenzymes, describing the organometallic structure of their active sites, the redox reactions in which they are involved, and their biogeochemical roles.
2023
Oxidoreductases and metal cofactors in the functioning of the earth / Hay Mele, Bruno; Monticelli, Maria; Leone, Serena; Bastoni, Deborah; Barosa, Bernardo; Cascone, Martina; Migliaccio, Flavia; Montemagno, Francesco; Ricciardelli, Annarita; Tonietti, Luca; Rotundi, Alessandra; Cordone, Angelina; Giovannelli, Donato. - In: ESSAYS IN BIOCHEMISTRY. - ISSN 0071-1365. - (2023). [10.1042/EBC20230012]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/933246
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