: Background The association between common carotid artery intima-media thickness (CCA-IMT) and incident carotid plaque has not been characterized fully. We therefore aimed to precisely quantify the relationship between CCA-IMT and carotid plaque development. Methods and Results We undertook an individual participant data meta-analysis of 20 prospective studies from the Proof-ATHERO (Prospective Studies of Atherosclerosis) consortium that recorded baseline CCA-IMT and incident carotid plaque involving 21 494 individuals without a history of cardiovascular disease and without preexisting carotid plaque at baseline. Mean baseline age was 56 years (SD, 9 years), 55% were women, and mean baseline CCA-IMT was 0.71 mm (SD, 0.17 mm). Over a median follow-up of 5.9 years (5th-95th percentile, 1.9-19.0 years), 8278 individuals developed first-ever carotid plaque. We combined study-specific odds ratios (ORs) for incident carotid plaque using random-effects meta-analysis. Baseline CCA-IMT was approximately log-linearly associated with the odds of developing carotid plaque. The age-, sex-, and trial arm-adjusted OR for carotid plaque per SD higher baseline CCA-IMT was 1.40 (95% CI, 1.31-1.50; I2=63.9%). The corresponding OR that was further adjusted for ethnicity, smoking, diabetes, body mass index, systolic blood pressure, low- and high-density lipoprotein cholesterol, and lipid-lowering and antihypertensive medication was 1.34 (95% CI, 1.24-1.45; I2=59.4%; 14 studies; 16 297 participants; 6381 incident plaques). We observed no significant effect modification across clinically relevant subgroups. Sensitivity analysis restricted to studies defining plaque as focal thickening yielded a comparable OR (1.38 [95% CI, 1.29-1.47]; I2=57.1%; 14 studies; 17 352 participants; 6991 incident plaques). Conclusions Our large-scale individual participant data meta-analysis demonstrated that CCA-IMT is associated with the long-term risk of developing first-ever carotid plaque, independent of traditional cardiovascular risk factors.
Association of Intima‐Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque: Individual Participant Data Meta‐Analysis of 20 Prospective Studies / Tschiderer, Lena; Seekircher, Lisa; Izzo, Raffaele; Mancusi, Costantino; Manzi, Maria V.; Baldassarre, Damiano; Amato, Mauro; Tremoli, Elena; Veglia, Fabrizio; Tuomainen, Tomi‐pekka; Kauhanen, Jussi; Voutilainen, Ari; Iglseder, Bernhard; Lind, Lars; Rundek, Tatjana; Desvarieux, Moise; Kato, Akihiko; de Groot, Eric; Aşçi, Gülay; Ok, Ercan; Agewall, Stefan; Beulens, Joline W. J.; Byrne, Christopher D.; Calder, Philip C.; Gerstein, Hertzel C.; Gresele, Paolo; Klingenschmid, Gerhard; Nagai, Michiaki; Olsen, Michael H.; Parraga, Grace; Safarova, Maya S.; Sattar, Naveed; Skilton, Michael; Stehouwer, Coen D. A.; Uthoff, Heiko; van Agtmael, Michiel A.; van der Heijden, Amber A.; Zozulińska‐ziółkiewicz, Dorota A.; Park, Hyun‐woong; Lee, Moo‐sik; Bae, Jang‐ho; Beloqui, Oscar; Landecho, Manuel F.; Plichart, Matthieu; Ducimetiere, Pierre; Philippe Empana, Jean; Bokemark, Lena; Bergström, Göran; Schmidt, Caroline; Castelnuovo, Samuela; Calabresi, Laura; Norata, Giuseppe D.; Grigore, Liliana; Catapano, Alberico; Zhao, Dong; Wang, Miao; Liu, Jing; Arfan Ikram, M.; Kavousi, Maryam; Bots, Michiel L.; Sweeting, Michael J.; Lorenz, Matthias W.; Willeit, Peter. - In: JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE. - ISSN 2047-9980. - (2023), p. e027657. [10.1161/JAHA.122.027657]
Association of Intima‐Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque: Individual Participant Data Meta‐Analysis of 20 Prospective Studies
Raffaele Izzo;Costantino Mancusi;Maria V. Manzi;Giuseppe D. Norata;
2023
Abstract
: Background The association between common carotid artery intima-media thickness (CCA-IMT) and incident carotid plaque has not been characterized fully. We therefore aimed to precisely quantify the relationship between CCA-IMT and carotid plaque development. Methods and Results We undertook an individual participant data meta-analysis of 20 prospective studies from the Proof-ATHERO (Prospective Studies of Atherosclerosis) consortium that recorded baseline CCA-IMT and incident carotid plaque involving 21 494 individuals without a history of cardiovascular disease and without preexisting carotid plaque at baseline. Mean baseline age was 56 years (SD, 9 years), 55% were women, and mean baseline CCA-IMT was 0.71 mm (SD, 0.17 mm). Over a median follow-up of 5.9 years (5th-95th percentile, 1.9-19.0 years), 8278 individuals developed first-ever carotid plaque. We combined study-specific odds ratios (ORs) for incident carotid plaque using random-effects meta-analysis. Baseline CCA-IMT was approximately log-linearly associated with the odds of developing carotid plaque. The age-, sex-, and trial arm-adjusted OR for carotid plaque per SD higher baseline CCA-IMT was 1.40 (95% CI, 1.31-1.50; I2=63.9%). The corresponding OR that was further adjusted for ethnicity, smoking, diabetes, body mass index, systolic blood pressure, low- and high-density lipoprotein cholesterol, and lipid-lowering and antihypertensive medication was 1.34 (95% CI, 1.24-1.45; I2=59.4%; 14 studies; 16 297 participants; 6381 incident plaques). We observed no significant effect modification across clinically relevant subgroups. Sensitivity analysis restricted to studies defining plaque as focal thickening yielded a comparable OR (1.38 [95% CI, 1.29-1.47]; I2=57.1%; 14 studies; 17 352 participants; 6991 incident plaques). Conclusions Our large-scale individual participant data meta-analysis demonstrated that CCA-IMT is associated with the long-term risk of developing first-ever carotid plaque, independent of traditional cardiovascular risk factors.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
