Background: To date, few cases of multiple sclerosis (MS) patients with concomitant Human Immunodeficiency Virus (HIV) infection have been described. However, none of the previously described cases has been treated with Natalizumab, probably due to the increasing risk of progressive multifocal leukoencephalopathy (PML). Case: We report the case of a patient concomitantly diagnosed for HIV infection and MS treated with combined antiretroviral therapy (cART) and Natalizumab for 19 months, without clinical or radiological MS activity. Conclusions: Our case might suggest considering Natalizumab in patients with concomitant HIV infection, especially for those with significant disease activity requiring a high efficacy disease modifying treatment.

Concomitant diagnosis of multiple sclerosis and human immunodeficiency virus (HIV) infection: case report and the review of literature / Trinchillo, Assunta; Spiezia, Antonio Luca; Carotenuto, Antonio; Tedeschi, Enrico; Servillo, Giuseppe; Iacovazzi, Carmine; Borrelli, Francesco; Di Filippo, Giovanni; Morra, Vincenzo Brescia; Lanzillo, Roberta. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-3478. - (2023). [10.1007/s10072-023-06727-7]

Concomitant diagnosis of multiple sclerosis and human immunodeficiency virus (HIV) infection: case report and the review of literature

Trinchillo, Assunta;Spiezia, Antonio Luca;Carotenuto, Antonio;Tedeschi, Enrico;Servillo, Giuseppe;Borrelli, Francesco;Morra, Vincenzo Brescia;Lanzillo, Roberta
2023

Abstract

Background: To date, few cases of multiple sclerosis (MS) patients with concomitant Human Immunodeficiency Virus (HIV) infection have been described. However, none of the previously described cases has been treated with Natalizumab, probably due to the increasing risk of progressive multifocal leukoencephalopathy (PML). Case: We report the case of a patient concomitantly diagnosed for HIV infection and MS treated with combined antiretroviral therapy (cART) and Natalizumab for 19 months, without clinical or radiological MS activity. Conclusions: Our case might suggest considering Natalizumab in patients with concomitant HIV infection, especially for those with significant disease activity requiring a high efficacy disease modifying treatment.
2023
Concomitant diagnosis of multiple sclerosis and human immunodeficiency virus (HIV) infection: case report and the review of literature / Trinchillo, Assunta; Spiezia, Antonio Luca; Carotenuto, Antonio; Tedeschi, Enrico; Servillo, Giuseppe; Iacovazzi, Carmine; Borrelli, Francesco; Di Filippo, Giovanni; Morra, Vincenzo Brescia; Lanzillo, Roberta. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-3478. - (2023). [10.1007/s10072-023-06727-7]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/915020
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