Aim: To evaluate the impact of a virtual educational camp (vEC) on glucose control in children and adolescents with type 1 diabetes using a closed-loop control (CLC) system. Materials and Methods: This was a prospective multicentre study of children and adolescents with type 1 diabetes using the Tandem Basal-IQ system. Insulin pumps were upgraded to Control-IQ, and children and their parents participated in a 3-day multidisciplinary vEC. Clinical data, glucose metrics and HbA1c were evaluated over the 12 weeks prior to the Control-IQ update and over the 12 weeks after the vEC. Results: Forty-three children and adolescents (aged 7-16 years) with type 1 diabetes and their families participated in the vEC. The median percentage of time in target range (70-180 mg/dL; TIR) increased from 64% (interquartile range [IQR] 56%-73%) with Basal-IQ to 76% (IQR 71%-81%) with Control-IQ (P <.001). After the vEC, more than 75% of participants achieved a TIR of more than 70%. The percentage of time between 180 and 250 mg/dL and above 250 mg/dL decreased by 5% (P <.01) and 6% (P <.01), respectively, while the time between 70 and 54 mg/dL and below 54 mg/dL remained low and unaltered. HbA1c decreased by 0.5% (P <.01). There were no episodes of diabetic ketoacidosis or severe hypoglycaemia. Conclusions: In this study of children managing their diabetes in a real-world setting, more than 75% of children who participated in a vEC after starting a CLC system could obtain and maintain a TIR of more than 70%. The vEC was feasible and resulted in a significant and persistent improvement in TIR in children and adolescents with type 1 diabetes.
Effectiveness of a closed-loop control system and a virtual educational camp for children and adolescents with type 1 diabetes: A prospective, multicentre, real-life study / Cherubini, V.; Rabbone, I.; Berioli, M. G.; Giorda, S.; Lo Presti, D.; Maltoni, G.; Mameli, C.; Marigliano, M.; Marino, M.; Minuto, N.; Mozzillo, E.; Piccinno, E.; Predieri, B.; Ripoli, C.; Schiaffini, R.; Rigamonti, A.; Salzano, G.; Tinti, D.; Toni, S.; Zanfardino, A.; Scaramuzza, A. E.; Gesuita, R.; Tiberi, V.; Savastio, S.; Pigniatiello, C.; Trada, M.; Zucchini, S.; Redaelli, F. C.; Maffeis, C.; Bassi, M.; Rosanio, F. M.; Delvecchio, M.; Buzzi, P.; Ricciardi, M. R.; Carducci, C.; Bonfanti, R.; Lombardo, F.; Piccini, B.; Iafusco, D.; Calandretti, M.; Daga, F. A.. - In: DIABETES, OBESITY AND METABOLISM. - ISSN 1462-8902. - 23:11(2021), pp. 2484-2491. [10.1111/dom.14491]
Effectiveness of a closed-loop control system and a virtual educational camp for children and adolescents with type 1 diabetes: A prospective, multicentre, real-life study
Mozzillo E.;Rosanio F. M.;Ricciardi M. R.;
2021
Abstract
Aim: To evaluate the impact of a virtual educational camp (vEC) on glucose control in children and adolescents with type 1 diabetes using a closed-loop control (CLC) system. Materials and Methods: This was a prospective multicentre study of children and adolescents with type 1 diabetes using the Tandem Basal-IQ system. Insulin pumps were upgraded to Control-IQ, and children and their parents participated in a 3-day multidisciplinary vEC. Clinical data, glucose metrics and HbA1c were evaluated over the 12 weeks prior to the Control-IQ update and over the 12 weeks after the vEC. Results: Forty-three children and adolescents (aged 7-16 years) with type 1 diabetes and their families participated in the vEC. The median percentage of time in target range (70-180 mg/dL; TIR) increased from 64% (interquartile range [IQR] 56%-73%) with Basal-IQ to 76% (IQR 71%-81%) with Control-IQ (P <.001). After the vEC, more than 75% of participants achieved a TIR of more than 70%. The percentage of time between 180 and 250 mg/dL and above 250 mg/dL decreased by 5% (P <.01) and 6% (P <.01), respectively, while the time between 70 and 54 mg/dL and below 54 mg/dL remained low and unaltered. HbA1c decreased by 0.5% (P <.01). There were no episodes of diabetic ketoacidosis or severe hypoglycaemia. Conclusions: In this study of children managing their diabetes in a real-world setting, more than 75% of children who participated in a vEC after starting a CLC system could obtain and maintain a TIR of more than 70%. The vEC was feasible and resulted in a significant and persistent improvement in TIR in children and adolescents with type 1 diabetes.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
