: COVID-19 is characterized by the immune system's overreaction resulting in a 'cytokine storm', consisting in a massive release of cytokine into the bloodstream, leading to local and systemic inflammatory response. This clinical picture is further complicated in case of infection of patients with a peculiar immunological status, such as pregnancy. In this paper, we focused on Interferon-γ, which plays a pivotal immunomodulatory role in normal pregnancy and fetal development, as well as in defense against pathogens. In this study, we compared the levels of Interferon-γ and the Interferon autoantibodies of the peripheral and cord blood of pregnant women with confirmed mild COVID-19 and healthy pregnant women. The Interferon-γ was significantly lower both in the peripheral and cord blood of SARS-CoV-2-positive mothers, suggesting that infection can affect the fetal microenvironment even without severe maternal symptoms. In conclusion, further studies are needed to clarify whether lower levels of Interferon-γ due to SARS-CoV-2 infection affect the development or infection susceptibility of infants born to SARS-CoV-2-infected mothers.

Low Interferon-γ Levels in Cord and Peripheral Blood of Pregnant Women Infected with SARS-CoV-2 / Cennamo, Michele; LA CIVITA, Evelina; Sarno, Laura; Carbone, Gianluigi; DI SOMMA, Sarah; Cabaro, Serena; Troisi, Jacopo; Sirico, Angelo; Improda, FRANCESCO PAOLO; Guida, Maurizio; Daniela, ; Portella, Giuseppe. - In: MICROORGANISMS. - ISSN 2076-2607. - 11:1(2023), p. 223. [10.3390/microorganisms11010223]

Low Interferon-γ Levels in Cord and Peripheral Blood of Pregnant Women Infected with SARS-CoV-2

Evelina La Civita;Laura SARNO;Gianluigi Carbone;Sarah Di Somma;Serena Cabaro;Angelo Sirico;francesco paolo improda;Maurizio Guida
;
Giuseppe PORTELLA
2023

Abstract

: COVID-19 is characterized by the immune system's overreaction resulting in a 'cytokine storm', consisting in a massive release of cytokine into the bloodstream, leading to local and systemic inflammatory response. This clinical picture is further complicated in case of infection of patients with a peculiar immunological status, such as pregnancy. In this paper, we focused on Interferon-γ, which plays a pivotal immunomodulatory role in normal pregnancy and fetal development, as well as in defense against pathogens. In this study, we compared the levels of Interferon-γ and the Interferon autoantibodies of the peripheral and cord blood of pregnant women with confirmed mild COVID-19 and healthy pregnant women. The Interferon-γ was significantly lower both in the peripheral and cord blood of SARS-CoV-2-positive mothers, suggesting that infection can affect the fetal microenvironment even without severe maternal symptoms. In conclusion, further studies are needed to clarify whether lower levels of Interferon-γ due to SARS-CoV-2 infection affect the development or infection susceptibility of infants born to SARS-CoV-2-infected mothers.
2023
Low Interferon-γ Levels in Cord and Peripheral Blood of Pregnant Women Infected with SARS-CoV-2 / Cennamo, Michele; LA CIVITA, Evelina; Sarno, Laura; Carbone, Gianluigi; DI SOMMA, Sarah; Cabaro, Serena; Troisi, Jacopo; Sirico, Angelo; Improda, FRANCESCO PAOLO; Guida, Maurizio; Daniela, ; Portella, Giuseppe. - In: MICROORGANISMS. - ISSN 2076-2607. - 11:1(2023), p. 223. [10.3390/microorganisms11010223]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/913030
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