Objectives: Oral lichen planus with exclusive keratotic reticular, papular, and/or plaque-like lesions (K-OLP) is a clinical pattern of OLP that may be associated with a complex symptomatology and psychological alteration. The aim of the study was to evaluate the prevalence of anxiety (A) and depression (D) in patients with K-OLP, analyzing the potential predictors which can affect mental health status. Methods: Three hundred K-OLP patients versus 300 healthy controls (HC) were recruited in 15 Italian universities. The Numeric Rating Scale (NRS), Total Pain Rating Index (T-PRI), and Hamilton Rating Scales for Depression and for Anxiety (HAM-D and HAM-A) were administered. Results: The K-OLP patients showed statistically higher scores in the NRS, T-PRI, HAM-D, and HAM-A compared with the HC (p-value < 0.001**). A and D were found in 158 (52.7%) and 148 (49.3%) K-OLP patients. Strong linear correlations were identified between HAM-A, HAM-D, NRS, T-PRI, and employment status and between HAM-D, HAM-A, NRS, T-PRI, employment status, and female gender. Multivariate logistic regression revealed that HAM-D and HAM-A showed the greatest increase in the R2 value for A and D in the K-OLP patients, respectively (DR2 = 55.5% p-value < 0.001**; DR2 = 56.5% p-value < 0.001**). Conclusions: The prevalence of A and D is higher in the K-OLP patients compared with the HC, also found in K-OLP subjects without pain, suggesting that the processing of pain may be in a certain way independent of the processing of mood. Clinical relevance: Mood disorders and pain assessment should be carefully performed in relation to K-OLP to obtain a complete analysis of the patients.

Anxiety and depression in keratotic oral lichen planus: a multicentric study from the SIPMO / Adamo, Daniela; Calabria, Elena; Canfora, Federica; Coppola, Noemi; Leuci, Stefania; Mignogna, Martina; Muzio, Lorenzo Lo; Spirito, Francesca; Giuliani, Michele; Azzi, Lorenzo; Dani, Marta; Colella, Giuseppe; Colella, Chiara; Montebugnoli, Lucio; Gissi, Davide Bartolomeo; Gabriele, Mario; Nisi, Marco; Sardella, Andrea; Lodi, Giovanni; Varoni, Elena Maria; Giudice, Amerigo; Antonelli, Alessandro; Gambino, Alessio; Antonucci, Giuliana; Vescovi, Paolo; Meleti, Marco; Majorana, Alessandra; Bardellini, Elena; Campisi, Giuseppina; Panzarella, Vera; Spadari, Francesco; Garagiola, Umberto; Pentenero, Monica; Sutera, Samuele; Biasotto, Matteo; Ottaviani, Giulia; Gobbo, Margherita; Nardini, Luca Guarda; Romeo, Umberto; Tenore, Gianluca; Serpico, Rosario; Lucchese, Alberta; Lajolo, Carlo; Gioco, Gioele; Aria, Massimo; D'Aniello, Luca; Mignogna, Michele Davide. - In: CLINICAL ORAL INVESTIGATIONS. - ISSN 1436-3771. - (2023). [10.1007/s00784-023-04909-3]

Anxiety and depression in keratotic oral lichen planus: a multicentric study from the SIPMO

Calabria, Elena;Canfora, Federica;Coppola, Noemi;Leuci, Stefania;Colella, Giuseppe;Colella, Chiara;Montebugnoli, Lucio;Gabriele, Mario;Campisi, Giuseppina;Aria, Massimo;D'Aniello, Luca;Mignogna, Michele Davide
2023

Abstract

Objectives: Oral lichen planus with exclusive keratotic reticular, papular, and/or plaque-like lesions (K-OLP) is a clinical pattern of OLP that may be associated with a complex symptomatology and psychological alteration. The aim of the study was to evaluate the prevalence of anxiety (A) and depression (D) in patients with K-OLP, analyzing the potential predictors which can affect mental health status. Methods: Three hundred K-OLP patients versus 300 healthy controls (HC) were recruited in 15 Italian universities. The Numeric Rating Scale (NRS), Total Pain Rating Index (T-PRI), and Hamilton Rating Scales for Depression and for Anxiety (HAM-D and HAM-A) were administered. Results: The K-OLP patients showed statistically higher scores in the NRS, T-PRI, HAM-D, and HAM-A compared with the HC (p-value < 0.001**). A and D were found in 158 (52.7%) and 148 (49.3%) K-OLP patients. Strong linear correlations were identified between HAM-A, HAM-D, NRS, T-PRI, and employment status and between HAM-D, HAM-A, NRS, T-PRI, employment status, and female gender. Multivariate logistic regression revealed that HAM-D and HAM-A showed the greatest increase in the R2 value for A and D in the K-OLP patients, respectively (DR2 = 55.5% p-value < 0.001**; DR2 = 56.5% p-value < 0.001**). Conclusions: The prevalence of A and D is higher in the K-OLP patients compared with the HC, also found in K-OLP subjects without pain, suggesting that the processing of pain may be in a certain way independent of the processing of mood. Clinical relevance: Mood disorders and pain assessment should be carefully performed in relation to K-OLP to obtain a complete analysis of the patients.
2023
Anxiety and depression in keratotic oral lichen planus: a multicentric study from the SIPMO / Adamo, Daniela; Calabria, Elena; Canfora, Federica; Coppola, Noemi; Leuci, Stefania; Mignogna, Martina; Muzio, Lorenzo Lo; Spirito, Francesca; Giuliani, Michele; Azzi, Lorenzo; Dani, Marta; Colella, Giuseppe; Colella, Chiara; Montebugnoli, Lucio; Gissi, Davide Bartolomeo; Gabriele, Mario; Nisi, Marco; Sardella, Andrea; Lodi, Giovanni; Varoni, Elena Maria; Giudice, Amerigo; Antonelli, Alessandro; Gambino, Alessio; Antonucci, Giuliana; Vescovi, Paolo; Meleti, Marco; Majorana, Alessandra; Bardellini, Elena; Campisi, Giuseppina; Panzarella, Vera; Spadari, Francesco; Garagiola, Umberto; Pentenero, Monica; Sutera, Samuele; Biasotto, Matteo; Ottaviani, Giulia; Gobbo, Margherita; Nardini, Luca Guarda; Romeo, Umberto; Tenore, Gianluca; Serpico, Rosario; Lucchese, Alberta; Lajolo, Carlo; Gioco, Gioele; Aria, Massimo; D'Aniello, Luca; Mignogna, Michele Davide. - In: CLINICAL ORAL INVESTIGATIONS. - ISSN 1436-3771. - (2023). [10.1007/s00784-023-04909-3]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/911973
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