: Hormonal abnormalities are quite common in chronic heart failure (CHF). The most studied hormonal axis in CHF is the impairment of Growth Hormone (GH)/Insulin Growth Factor-1(IGF-1), which in turn is defined either by a blunted response to GH stimulation test or low serum IGF-1 values. Several independent groups reported that the presence of an abnormal GH/IGF-1 status in CHF is associated with a more severe disease, impaired functional capacity and reduced Survival rates. After the first encouraging results, double -blind controlled trials showed a neutral effect of the GH administration in patients. However, further studies reported positive results, when a GH-therapy is implemented only in those patients presenting a GH deficiency (replacement therapy).
The impairment of the Growth Hormone/Insulin-like growth factor 1 (IGF-1) axis in heart failure: A possible target for future therapy / Piccioli, Lucrezia; Arcopinto, Michele; Salzano, Andrea; D'Assante, Roberta; Schiavo, Alessandra; Stagnaro, Francesca M.; Lombardi, Anna; Panicara, Veronica; Valente, Pietro; Vitale, Giuseppe; Sarullo, Filippo M.; Giallauria, Francesco; Marra, Alberto M.. - In: MONALDI ARCHIVES FOR CHEST DISEASE. - ISSN 2532-5264. - 88:3(2018), pp. 20-25. [10.4081/monaldi.2018.975]
The impairment of the Growth Hormone/Insulin-like growth factor 1 (IGF-1) axis in heart failure: A possible target for future therapy
Lucrezia Piccioli;Michele Arcopinto;Andrea Salzano;Roberta D'Assante;Alessandra Schiavo;Francesca M. Stagnaro;Veronica Panicara;Pietro Valente;Francesco Giallauria;Alberto M. Marra
2018
Abstract
: Hormonal abnormalities are quite common in chronic heart failure (CHF). The most studied hormonal axis in CHF is the impairment of Growth Hormone (GH)/Insulin Growth Factor-1(IGF-1), which in turn is defined either by a blunted response to GH stimulation test or low serum IGF-1 values. Several independent groups reported that the presence of an abnormal GH/IGF-1 status in CHF is associated with a more severe disease, impaired functional capacity and reduced Survival rates. After the first encouraging results, double -blind controlled trials showed a neutral effect of the GH administration in patients. However, further studies reported positive results, when a GH-therapy is implemented only in those patients presenting a GH deficiency (replacement therapy).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.