: Anabolic deficiencies play a pivotal role in left-sided heart failure. Little is known about their impact on idiopathic pulmonary arterial hypertension (iPAH). Therefore, the aim of this study was to assess the impact of multiple hormone-metabolic deficiencies on clinical features and outcomes in idiopathic pulmonary arterial hypertension. We have demonstrated that the assessment of anabolic hormone levels in patients with iPAH allows the identification of a subpopulation with worse exercise capacity, pulmonary hemodynamics, right ventricular size, and function generating the hypothesis about the potential role of hormonal replacement therapy. These data should be confirmed by larger studies.

Impact of Hormonal-Anabolic Deficiencies in Idiopathic Pulmonary Arterial Hypertension / Marra, Alberto M; D'Agostino, Anna; Salzano, Andrea; Basili, Stefania; D'Alto, Michele; Bossone, Eduardo; Cittadini, Antonio; Vizza, Carmine Dario; Badagliacca, Roberto. - In: HEART FAILURE CLINICS. - ISSN 1551-7136. - 19:1(2023), pp. 115-123. [10.1016/j.hfc.2022.09.001]

Impact of Hormonal-Anabolic Deficiencies in Idiopathic Pulmonary Arterial Hypertension

Marra, Alberto M
Primo
;
Salzano, Andrea;Bossone, Eduardo;Cittadini, Antonio;
2023

Abstract

: Anabolic deficiencies play a pivotal role in left-sided heart failure. Little is known about their impact on idiopathic pulmonary arterial hypertension (iPAH). Therefore, the aim of this study was to assess the impact of multiple hormone-metabolic deficiencies on clinical features and outcomes in idiopathic pulmonary arterial hypertension. We have demonstrated that the assessment of anabolic hormone levels in patients with iPAH allows the identification of a subpopulation with worse exercise capacity, pulmonary hemodynamics, right ventricular size, and function generating the hypothesis about the potential role of hormonal replacement therapy. These data should be confirmed by larger studies.
2023
Impact of Hormonal-Anabolic Deficiencies in Idiopathic Pulmonary Arterial Hypertension / Marra, Alberto M; D'Agostino, Anna; Salzano, Andrea; Basili, Stefania; D'Alto, Michele; Bossone, Eduardo; Cittadini, Antonio; Vizza, Carmine Dario; Badagliacca, Roberto. - In: HEART FAILURE CLINICS. - ISSN 1551-7136. - 19:1(2023), pp. 115-123. [10.1016/j.hfc.2022.09.001]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/907921
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