: Cystic fibrosis is a hereditary metabolic disorder characterized by impaired traffic of chloride ions and water through membranes of the respiratory and gastrointestinal, that causes inadequate hydration of airway surfaces, dehydrated mucous secretions and a high-sodium chloride sweat. Although the classical presentation of the condition is well known, a better characterization of metabolic alterations related is need. In particular, the metabolic composition alterations of biological fluids may be influence by the disease state and could be captured as putative signature to set targeted therapeutic strategies. A targeted comprehensive mass spectrometry-based platform was employed to dissect the lipid content of saliva samples form CF patients, in order to investigate alterations in the lipid metabolic homeostasis related to the pathology, chronic obstructive pulmonary disease, Pseudomonas Aeruginosa infection, pancreatic insufficiency, liver disfunction and diabetes-related complications.

Lipidomic alterations in human saliva from cystic fibrosis patients / Caterino, Marianna; Fedele, Roberta; Carnovale, Vincenzo; Castaldo, Alice; Gelzo, Monica; Iacotucci, Paola; Ruoppolo, Margherita; Castaldo, Giuseppe. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 13:article number 600(2023), pp. 1-15. [10.1038/s41598-022-24429-6]

Lipidomic alterations in human saliva from cystic fibrosis patients

Caterino Marianna
Primo
;
Carnovale Vincenzo;Castaldo Alice;Gelzo Monica;Iacotucci Paola;Ruoppolo Margherita;Castaldo Giuseppe
2023

Abstract

: Cystic fibrosis is a hereditary metabolic disorder characterized by impaired traffic of chloride ions and water through membranes of the respiratory and gastrointestinal, that causes inadequate hydration of airway surfaces, dehydrated mucous secretions and a high-sodium chloride sweat. Although the classical presentation of the condition is well known, a better characterization of metabolic alterations related is need. In particular, the metabolic composition alterations of biological fluids may be influence by the disease state and could be captured as putative signature to set targeted therapeutic strategies. A targeted comprehensive mass spectrometry-based platform was employed to dissect the lipid content of saliva samples form CF patients, in order to investigate alterations in the lipid metabolic homeostasis related to the pathology, chronic obstructive pulmonary disease, Pseudomonas Aeruginosa infection, pancreatic insufficiency, liver disfunction and diabetes-related complications.
2023
Lipidomic alterations in human saliva from cystic fibrosis patients / Caterino, Marianna; Fedele, Roberta; Carnovale, Vincenzo; Castaldo, Alice; Gelzo, Monica; Iacotucci, Paola; Ruoppolo, Margherita; Castaldo, Giuseppe. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 13:article number 600(2023), pp. 1-15. [10.1038/s41598-022-24429-6]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/906899
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