Intermolecular couplings of simple building blocks using catalytic, stereoselective cross-Mannich reactions followed by intramolecular functional group-pairing reactions of easily accessed variants of the Mannich products are explored as a route to skeletally diverse small molecules. The synthetic pathway yields products having 12 different skeletons using only three steps and has the potential to enable substantial stereochemical diversification in the future.

Skeletally Diverse Small Molecules Using a Build/Couple/Pair Strategy / Takuya, Uchida; Rodriquez, Manuela; STUART L., Schreiber. - In: ORGANIC LETTERS. - ISSN 1523-7060. - 11 (7):(2009), pp. 1559-1562. [10.1021/ol900173t]

Skeletally Diverse Small Molecules Using a Build/Couple/Pair Strategy

RODRIQUEZ, Manuela;
2009

Abstract

Intermolecular couplings of simple building blocks using catalytic, stereoselective cross-Mannich reactions followed by intramolecular functional group-pairing reactions of easily accessed variants of the Mannich products are explored as a route to skeletally diverse small molecules. The synthetic pathway yields products having 12 different skeletons using only three steps and has the potential to enable substantial stereochemical diversification in the future.
2009
Skeletally Diverse Small Molecules Using a Build/Couple/Pair Strategy / Takuya, Uchida; Rodriquez, Manuela; STUART L., Schreiber. - In: ORGANIC LETTERS. - ISSN 1523-7060. - 11 (7):(2009), pp. 1559-1562. [10.1021/ol900173t]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/906413
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