: Sentinel lymph node (SLN) sampling is important for evaluating the nodal stage of breast cancer when the axillary nodes are clinically free of metastasis. The intraoperative frozen section (IFS) of SLN is used for lymph node assessment. This meta-analysis aims to provide evidence about the diagnostic accuracy and the applicability of IFS of SLN in breast cancer patients. Data were collected by searching PubMed, Cochrane, Scopus, and Web of Science electronic databases for trials matching our eligibility criteria. The statistical analysis included the sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and pooled studies' diagnostic odds ratio outcomes. The analyses were conducted using the Open Meta-analyst software. This meta-analysis pooled the results of 110 studies. The overall sensitivity of IFS for SLN metastasis was 74.7%; 95% CI [72.0, 77.2], P < 0.001. It was 31.4% 95% CI [25.2, 38.3], P < 0.001 for the micro-metastasis, and 90.2%; 95% CI [86.5, 93.0], P < 0.001 for the macro-metastasis. The overall specificity was 99.4%; 95% CI [99.2, 99.6], P < 0.001. The overall positive likelihood ratio was 121.4; 95% CI [87.9, 167.6], P < 0.001, and the overall negative likelihood ratio was 0.226; 95% CI [0.186, 0.274], P < 0.001. The overall diagnostic odds ratio of IFS for diagnosing SLN metastasis was 569.5; 95% CI [404.2, 802.4], P < 0.001. The intraoperative frozen section of SLN has good sensitivity for diagnosing breast cancer macro-metastasis. However, the sensitivity is low for micro-metastasis. The specificity is very satisfactory.

The diagnostic accuracy of intraoperative frozen section biopsy for diagnosis of sentinel lymph node metastasis in breast cancer patients: a meta-analysis / Elshanbary, Alaa Ahmed; Awad, Alaa Abdelsameia; Abdelsalam, Alaa; Ibrahim, Islam H; Abdel-Aziz, Walid; Darwish, Youssef Bahaaeldin; Isa, Alaa Saad; Drid, Boutheyna; Mustafa, Marwa Gamal; Allam, Radwa Hamdy; Abo Ali, Amira A; Nourelden, Anas Zakarya; Ragab, Khaled Mohamed; Algwaiz, Hussah I M; Awaji, Aeshah A; Germoush, Mousa O; Albrakati, Ashraf; Piscopo, Marina; Ghaboura, Nehmat; Zaazouee, Mohamed Sayed. - In: ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH INTERNATIONAL. - ISSN 0944-1344. - 29:32(2022), pp. 47931-47941. [10.1007/s11356-022-20569-4]

The diagnostic accuracy of intraoperative frozen section biopsy for diagnosis of sentinel lymph node metastasis in breast cancer patients: a meta-analysis

Piscopo, Marina;
2022

Abstract

: Sentinel lymph node (SLN) sampling is important for evaluating the nodal stage of breast cancer when the axillary nodes are clinically free of metastasis. The intraoperative frozen section (IFS) of SLN is used for lymph node assessment. This meta-analysis aims to provide evidence about the diagnostic accuracy and the applicability of IFS of SLN in breast cancer patients. Data were collected by searching PubMed, Cochrane, Scopus, and Web of Science electronic databases for trials matching our eligibility criteria. The statistical analysis included the sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and pooled studies' diagnostic odds ratio outcomes. The analyses were conducted using the Open Meta-analyst software. This meta-analysis pooled the results of 110 studies. The overall sensitivity of IFS for SLN metastasis was 74.7%; 95% CI [72.0, 77.2], P < 0.001. It was 31.4% 95% CI [25.2, 38.3], P < 0.001 for the micro-metastasis, and 90.2%; 95% CI [86.5, 93.0], P < 0.001 for the macro-metastasis. The overall specificity was 99.4%; 95% CI [99.2, 99.6], P < 0.001. The overall positive likelihood ratio was 121.4; 95% CI [87.9, 167.6], P < 0.001, and the overall negative likelihood ratio was 0.226; 95% CI [0.186, 0.274], P < 0.001. The overall diagnostic odds ratio of IFS for diagnosing SLN metastasis was 569.5; 95% CI [404.2, 802.4], P < 0.001. The intraoperative frozen section of SLN has good sensitivity for diagnosing breast cancer macro-metastasis. However, the sensitivity is low for micro-metastasis. The specificity is very satisfactory.
2022
The diagnostic accuracy of intraoperative frozen section biopsy for diagnosis of sentinel lymph node metastasis in breast cancer patients: a meta-analysis / Elshanbary, Alaa Ahmed; Awad, Alaa Abdelsameia; Abdelsalam, Alaa; Ibrahim, Islam H; Abdel-Aziz, Walid; Darwish, Youssef Bahaaeldin; Isa, Alaa Saad; Drid, Boutheyna; Mustafa, Marwa Gamal; Allam, Radwa Hamdy; Abo Ali, Amira A; Nourelden, Anas Zakarya; Ragab, Khaled Mohamed; Algwaiz, Hussah I M; Awaji, Aeshah A; Germoush, Mousa O; Albrakati, Ashraf; Piscopo, Marina; Ghaboura, Nehmat; Zaazouee, Mohamed Sayed. - In: ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH INTERNATIONAL. - ISSN 0944-1344. - 29:32(2022), pp. 47931-47941. [10.1007/s11356-022-20569-4]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/905989
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